多胺氧化酶-多胺系统对人中性粒细胞运动的抑制作用。
Inhibition of human neutrophil locomotion by the polyamine oxidase-polyamine system.
作者信息
Ferrante A
出版信息
Immunology. 1985 Apr;54(4):785-90.
Abstract
The polyamines, spermine and spermidine, in the presence of either bovine serum [containing polyamine oxidase (PAO) activity] or partially purified PAO, inhibited human neutrophil locomotion. This effect could not be produced by either bovine serum, PAO, or the polyamines alone. The results suggested that at least two of the products generated during the oxidation of polyamines by PAO, namely H2O2 and ammonia, are not responsible for the effects on neutrophils. Acrolein, a breakdown product of other products (aminoaldehydes), was found to inhibit the neutrophil functions. Since polyamines, and possibly PAOs, accumulate at inflammatory sites, products of the PAO-polyamine reaction could function as regulators of the inflammatory response.
摘要
在含有多胺氧化酶（PAO）活性的牛血清或部分纯化的PAO存在的情况下，多胺、精胺和亚精胺会抑制人类中性粒细胞的运动。单独的牛血清、PAO或多胺都不会产生这种效果。结果表明，PAO氧化多胺过程中产生的至少两种产物，即过氧化氢和氨，对中性粒细胞的影响并不起作用。丙烯醛是其他产物（氨基醛）的分解产物，被发现可抑制中性粒细胞功能。由于多胺以及可能的PAO在炎症部位积累，PAO - 多胺反应的产物可能作为炎症反应的调节剂发挥作用。
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