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曼氏血吸虫童虫、犬恶丝虫微丝蚴和Dubius线虫三期幼虫对多胺氧化酶-多胺系统损伤的敏感性差异。

Differences in sensitivity of Schistosoma mansoni schistosomula, Dirofilaria immitis microfilariae, and Nematospiroides dubius third-stage larvae to damage by the polyamine oxidase-polyamine system.

作者信息

Ferrante A, Ljungstrom I, Rzepczyk C M, Morgan D M

出版信息

Infect Immun. 1986 Sep;53(3):606-10. doi: 10.1128/iai.53.3.606-610.1986.

DOI:10.1128/iai.53.3.606-610.1986
PMID:3744554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC260834/
Abstract

The effect of the polyamine oxidase (PAO)-polyamine system on some helminths was examined in vitro. Both Schistosoma mansoni schistosomula and Dirofilaria immitis microfilariae were highly sensitive to this system, the latter more so than the former. In contrast, exsheathed third-stage larvae of Nematospiroides dubius were resistant to the effects of the PAO-polyamine system. After incubation of microfilariae with either spermine or spermidine in the presence of serum containing PAO (bovine serum or human retroplacental serum) or partially purified PAO, damage of worms occurred, compatible with our criteria for worm death. Similar results were obtained with schistosomula by using spermine. The damage seemed to be mediated by PAO products other than hydrogen peroxide because catalase did not protect either parasite. Our data demonstrate that helminths may be damaged by products of the PAO-polyamine system.

摘要

在体外研究了多胺氧化酶（PAO）-多胺系统对某些蠕虫的作用。曼氏血吸虫童虫和犬恶丝虫微丝蚴对该系统均高度敏感，后者比前者更敏感。相比之下，脱鞘的杜氏线虫第三期幼虫对PAO-多胺系统的作用具有抗性。在含有PAO的血清（牛血清或人胎盘后血清）或部分纯化的PAO存在下，将微丝蚴与精胺或亚精胺一起孵育后，蠕虫出现损伤，符合我们关于蠕虫死亡的标准。使用精胺对血吸虫童虫也得到了类似结果。这种损伤似乎是由除过氧化氢以外的PAO产物介导的，因为过氧化氢酶不能保护任何一种寄生虫。我们的数据表明，PAO-多胺系统的产物可能会损伤蠕虫。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd72/260834/b03f1565ffe9/iai00102-0170-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd72/260834/0c39aa1c3678/iai00102-0169-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd72/260834/b03f1565ffe9/iai00102-0170-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd72/260834/0c39aa1c3678/iai00102-0169-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd72/260834/b03f1565ffe9/iai00102-0170-a.jpg

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本文引用的文献

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Polyamine oxidase in rat tissues.大鼠组织中的多胺氧化酶。
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Polyamine-polyamine oxidase interaction: part of maternal protective mechanism against fetal rejection.多胺-多胺氧化酶相互作用：母体防止胎儿排斥反应保护机制的一部分。
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Polyamine oxidase-mediated killing of African trypanosomes.多胺氧化酶介导的非洲锥虫杀伤作用。
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In vitro immune mechanisms associated with clearance of microfilariae of Dirofilaria immitis.与犬恶丝虫微丝蚴清除相关的体外免疫机制。
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Immunological and ultrastructural aspects of the cell-mediated killing of Dirofilaria immitis microfilariae.细胞介导杀灭犬恶丝虫微丝蚴的免疫学及超微结构研究
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Polyamine oxidase-mediated trypanosome killing: the role of hydrogen peroxide and aldehydes.多胺氧化酶介导的锥虫杀伤作用：过氧化氢和醛类的作用
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Polyamine oxidase mediates intra-erythrocytic death of Plasmodium falciparum.多胺氧化酶介导恶性疟原虫的红细胞内死亡。
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