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Are patients with chronic rhinosinusitis with nasal polyps at a decreased risk of COVID-19 infection?

作者信息

Saheb Sharif-Askari Fatemeh, Saheb Sharif-Askari Narjes, Goel Swati, Fakhri Samer, Al-Muhsen Saleh, Hamid Qutayba, Halwani Rabih

机构信息

Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Department of Otorhinolaryngology-Head & Neck Surgery, Faculty of Medicine and AUBMC, American University of Beirut, Beirut, Lebanon.

出版信息

Int Forum Allergy Rhinol. 2020 Oct;10(10):1182-1185. doi: 10.1002/alr.22672. Epub 2020 Aug 19.

DOI:10.1002/alr.22672
PMID:32757347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7436719/
Abstract
摘要

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本文引用的文献

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Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD.儿童气道中严重急性呼吸综合征冠状病毒2（SARS-CoV-2）受体血管紧张素转换酶2（ACE2）和跨膜丝氨酸蛋白酶2（TMPRSS2）的表达低于成人，并随吸烟和慢性阻塞性肺疾病（COPD）而增加。
Mol Ther Methods Clin Dev. 2020 May 22;18:1-6. doi: 10.1016/j.omtm.2020.05.013. eCollection 2020 Sep 11.
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SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.SARS-CoV-2 反向遗传学揭示了呼吸道感染的可变梯度。
Cell. 2020 Jul 23;182(2):429-446.e14. doi: 10.1016/j.cell.2020.05.042. Epub 2020 May 27.
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Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells.2 型炎症调节气道上皮细胞中的 ACE2 和 TMPRSS2。
J Allergy Clin Immunol. 2020 Jul;146(1):80-88.e8. doi: 10.1016/j.jaci.2020.05.004. Epub 2020 May 15.
4
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.SARS-CoV-2 受体 ACE2 是人类气道上皮细胞中的一种干扰素刺激基因，可在组织中的特定细胞亚群中检测到。
Cell. 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. Epub 2020 Apr 27.
5
COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids.哮喘患者痰液细胞中的 COVID-19 相关基因。与人口统计学特征和皮质类固醇的关系。
Am J Respir Crit Care Med. 2020 Jul 1;202(1):83-90. doi: 10.1164/rccm.202003-0821OC.
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Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2.呼吸道过敏、哮喘与新型冠状病毒受体血管紧张素转换酶2表达的关联。
J Allergy Clin Immunol. 2020 Jul;146(1):203-206.e3. doi: 10.1016/j.jaci.2020.04.009. Epub 2020 Apr 22.
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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）进入因子与固有免疫基因一起在鼻上皮细胞中高表达。
Nat Med. 2020 May;26(5):681-687. doi: 10.1038/s41591-020-0868-6. Epub 2020 Apr 23.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）进入细胞依赖于 ACE2 和 TMPRSS2，可被一种临床验证的蛋白酶抑制剂所阻断。
Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.
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SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients.感染患者上呼吸道标本中的新型冠状病毒2型病毒载量
N Engl J Med. 2020 Mar 19;382(12):1177-1179. doi: 10.1056/NEJMc2001737. Epub 2020 Feb 19.
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A pneumonia outbreak associated with a new coronavirus of probable bat origin.一种新型冠状病毒引发的肺炎疫情，该病毒可能来源于蝙蝠。
Nature. 2020 Mar;579(7798):270-273. doi: 10.1038/s41586-020-2012-7. Epub 2020 Feb 3.