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以类风湿关节炎表现的麻风病误导正确诊断。

Leprosy-Presenting as Rheumatoid Arthritis Misleading the Correct Diagnosis.

作者信息

Sagar Dhakal, Kipa Shrestha, Praful Gurung, Durga Thapa

机构信息

Department of Orthopaedics and Trauma Surgery Patan Academy of Health Sciences Lagankhel Lalitpur Nepal.

Amppipal Hospital Gorkha Nepal.

出版信息

Clin Case Rep. 2025 Jan 10;13(1):e70096. doi: 10.1002/ccr3.70096. eCollection 2025 Jan.

DOI:10.1002/ccr3.70096
PMID:39802362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11720720/
Abstract

Leprosy can present with symptoms resembling rheumatoid arthritis, leading to delays in diagnosis or inappropriate treatment, potentially progressing to lepromatous forms, neuropathy, and disability. Physicians must consider leprosy as a differential for rheumatoid arthritis, especially in endemic regions. Early detection is vital to prevent chronic neuropathy, disabilities, and disfigurement.

摘要

麻风病可能会出现类似类风湿性关节炎的症状，导致诊断延误或治疗不当，有可能发展为瘤型麻风、神经病变和残疾。医生必须将麻风病列为类风湿性关节炎的鉴别诊断疾病，尤其是在麻风病流行地区。早期发现对于预防慢性神经病变、残疾和毁容至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba72/11720720/ef262c37870e/CCR3-13-e70096-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba72/11720720/c52adec59735/CCR3-13-e70096-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba72/11720720/eeb03ca1c866/CCR3-13-e70096-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba72/11720720/22118823d378/CCR3-13-e70096-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba72/11720720/e76f102a69c8/CCR3-13-e70096-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba72/11720720/ef262c37870e/CCR3-13-e70096-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba72/11720720/c52adec59735/CCR3-13-e70096-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba72/11720720/eeb03ca1c866/CCR3-13-e70096-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba72/11720720/22118823d378/CCR3-13-e70096-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba72/11720720/e76f102a69c8/CCR3-13-e70096-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba72/11720720/ef262c37870e/CCR3-13-e70096-g003.jpg

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本文引用的文献

1
Leprosy Classification, Clinical Features, Epidemiology, and Host Immunological Responses: Failure of Eradication in 2023.麻风病的分类、临床特征、流行病学及宿主免疫反应：2023年根除失败情况
Cureus. 2023 Sep 6;15(9):e44767. doi: 10.7759/cureus.44767. eCollection 2023 Sep.
2
Leonine facies and madarosis in lepromatous leprosy.瘤型麻风的狮面和睫毛脱落
Postgrad Med J. 2022 Dec;98(1166):e36. doi: 10.1136/postgradmedj-2021-141061. Epub 2021 Sep 29.
3
Case Report: Leprosy Osteoarticular Alterations Mimicking Rheumatoid Arthritis.
病例报告：类风关样麻风性骨关节改变
Am J Trop Med Hyg. 2020 Jun;102(6):1316-1318. doi: 10.4269/ajtmh.19-0723.
4
Epidemiological aspects of leprosy.麻风病的流行病学方面。
Dis Mon. 2020 Jul;66(7):100899. doi: 10.1016/j.disamonth.2019.100899. Epub 2019 Dec 2.
5
Leprosy - eliminated and forgotten: a case report.麻风病——已被消除却被遗忘：一例病例报告
J Med Case Rep. 2019 Sep 1;13(1):276. doi: 10.1186/s13256-019-2198-1.
6
Utility of multiplex PCR for early diagnosis and household contact surveillance for leprosy.多重聚合酶链反应在麻风病早期诊断和家庭接触监测中的应用。
Diagn Microbiol Infect Dis. 2019 Nov;95(3):114855. doi: 10.1016/j.diagmicrobio.2019.06.007. Epub 2019 Jun 20.
7
Leprosy: A Great Mimicking Disease.麻风病：一种极具伪装性的疾病。
Indian J Lepr. 2016 Apr;88(2):123-127.
8
Lepromatous leprosy simulating rheumatoid arthritis - Report of a neglected disease.模拟类风湿关节炎的瘤型麻风——一种被忽视疾病的报告
An Bras Dermatol. 2017 May-Jun;92(3):389-391. doi: 10.1590/abd1806-4841.20175423.
9
Leprosy in the 21st century.21世纪的麻风病
Clin Microbiol Rev. 2015 Jan;28(1):80-94. doi: 10.1128/CMR.00079-13.
10
Leprosy mimicking common rheumatologic entities: a trial for the clinician in the era of biologics.类麻风的常见风湿性疾病：生物制剂时代临床医生面临的考验
Case Rep Rheumatol. 2014;2014:429698. doi: 10.1155/2014/429698. Epub 2014 Nov 6.