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尼科劳综合征：皮下免疫治疗后发生缺血性坏死1例。

Nicolau syndrome: A case of ischemic necrosis after subcutaneous immunotherapy.

作者信息

Kim Joyce, Kaddis Tim, Boyle Spencer, Gupta Sandeep, Wang Vivian, Yusin Joseph

机构信息

Department of Medicine, University of California Los Angeles, Los Angeles, Calif.

Division of Allergy and Immunology, Greater Los Angeles VA Medical Center, Los Angeles, Calif.

出版信息

J Allergy Clin Immunol Glob. 2024 Nov 26;4(1):100375. doi: 10.1016/j.jacig.2024.100375. eCollection 2025 Feb.

DOI:10.1016/j.jacig.2024.100375
PMID:39802396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11719306/
Abstract

A rare injection site reaction known as Nicolau syndrome can occur in patients receiving subcutaneous immunotherapy. This syndrome has been reported only a handful of times in the literature related to subcutaneous immunotherapy.

摘要

一种名为尼科劳综合征的罕见注射部位反应可能发生在接受皮下免疫治疗的患者身上。在与皮下免疫治疗相关的文献中，这种综合征仅被报道过少数几次。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed07/11719306/d55ba62497c5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed07/11719306/d55ba62497c5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed07/11719306/d55ba62497c5/gr1.jpg

相似文献

1
Nicolau syndrome: A case of ischemic necrosis after subcutaneous immunotherapy.尼科劳综合征：皮下免疫治疗后发生缺血性坏死1例。
J Allergy Clin Immunol Glob. 2024 Nov 26;4(1):100375. doi: 10.1016/j.jacig.2024.100375. eCollection 2025 Feb.
2
Nicolau's syndrome: A rare but preventable iatrogenic disease.尼科劳综合征：一种罕见但可预防的医源性疾病。
Acta Dermatovenerol Croat. 2017 Oct;25(3):251-253.
3
Nicolau Syndrome (Embolia Cutis Medicamentosa): A Rare and Poorly Recognized Iatrogenic Cause of Cutaneous Thrombotic Vasculopathy.尼科劳综合征（药物性皮肤栓塞）：一种罕见且认识不足的医源性皮肤血栓性血管病病因。
Am J Dermatopathol. 2018 Mar;40(3):212-215. doi: 10.1097/DAD.0000000000000972.
4
Embolia cutis Medicamentosa (Nicolau syndrome): case series.药物性皮肤栓塞（尼科劳综合征）：病例系列
Front Med (Lausanne). 2023 Nov 2;10:1216781. doi: 10.3389/fmed.2023.1216781. eCollection 2023.
5
Nicolau syndrome following subcutaneous glatiramer acetate injection: A case report and review of the literature.皮下注射格拉替雷后尼科劳综合征：病例报告及文献复习。
Indian J Pharmacol. 2021 Nov-Dec;53(6):489-492. doi: 10.4103/ijp.ijp_166_21.
6
Nicolau Syndrome Secondary to Subcutaneous Glatiramer Acetate Injection.皮下注射醋酸格拉替雷继发的尼科劳综合征
Int J Low Extrem Wounds. 2023 Mar;22(1):149-151. doi: 10.1177/1534734620973144. Epub 2020 Dec 1.
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Embolia Cutis Medicamentosa (Nicolau Syndrome) Secondary to Intramuscular Fulvestrant Injection: A Case Report.肌肉内注射氟维司群致药物性皮肤栓塞（尼科劳斯综合征）：1 例报告。
J Pharm Pract. 2022 Dec;35(6):1034-1038. doi: 10.1177/08971900211012263. Epub 2021 Apr 29.
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[Embolia cutis medicamentosa (Nicolau syndrome) after intra-articular injection].关节腔内注射后发生的药物性皮肤栓塞（尼古劳综合征）
Hautarzt. 1999 Mar;50(3):214-6. doi: 10.1007/s001050050892.
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Nicolau syndrome caused by Glatiramer.由格拉替雷引起的尼科劳综合征。
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[Nicolau syndrome induced by intramuscular injection of a hexavalent vaccine in a 6-month-old girl].[一名6个月大女童因肌内注射六价疫苗诱发尼科拉乌综合征]
Arch Argent Pediatr. 2017 Feb 1;115(1):e13-e16. doi: 10.5546/aap.2017.e13.

本文引用的文献

1
Skin necrosis following local anesthetic: Same presentation for two different diagnoses.
Asian Pac J Allergy Immunol. 2024 Dec;42(4):372-374. doi: 10.12932/AP-100721-1183.
2
Nicolau syndrome following subcutaneous glatiramer acetate injection: A case report and review of the literature.皮下注射格拉替雷后尼科劳综合征：病例报告及文献复习。
Indian J Pharmacol. 2021 Nov-Dec;53(6):489-492. doi: 10.4103/ijp.ijp_166_21.
3
Nicolau Syndrome: An Unforeseen Yet Evadable Consequence of Intramuscular Injection.尼科劳综合征：肌肉注射一种意想不到但可避免的后果。
Surg J (N Y). 2021 May 25;7(2):e62-e65. doi: 10.1055/s-0041-1728652. eCollection 2021 Apr.
4
Subcutaneous Immunotherapy Induced Local Skin Necrosis.皮下免疫疗法诱发局部皮肤坏死。
J Allergy Clin Immunol Pract. 2019 Sep-Oct;7(7):2402-2403. doi: 10.1016/j.jaip.2019.03.047. Epub 2019 May 2.
5
Tissue loss with subcutaneous immunotherapy--Nicolau syndrome.皮下免疫疗法导致的组织损伤——尼科劳综合征。
J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):154-5. doi: 10.1016/j.jaip.2015.07.014. Epub 2015 Sep 8.
6
Nicolau syndrome: an iatrogenic cutaneous necrosis.尼科劳综合征：一种医源性皮肤坏死。
J Cutan Aesthet Surg. 2009 Jul;2(2):92-5. doi: 10.4103/0974-2077.58523.
7
Nicolau syndrome aggravated by cold application after i.m. diclofenac.肌内注射双氯芬酸后冷敷加重尼科劳综合征。
J Dermatol. 2008 Jan;35(1):18-20. doi: 10.1111/j.1346-8138.2007.00404.x.
8
Nicolau syndrome following intramuscular diclofenac administration: a case report.肌肉注射双氯芬酸后发生的尼科劳综合征：一例报告。
J Orthop Surg (Hong Kong). 2006 Apr;14(1):104-7. doi: 10.1177/230949900601400123.