Khamar Faezeh, Atabaki Mahdi, Samadi Morteza, Reisi Marzieh, Sandoughi Mahnaz
Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Rheumatol Immunol Res. 2025 Jan 9;5(4):227-234. doi: 10.1515/rir-2024-0031. eCollection 2024 Dec.
Rheumatoid arthritis (RA) is a well-known systemic autoimmune inflammatory disease. This investigation aimed to assess the effects of Sina-curcumin, a novel nano micelle-based curcumin, on immune system responses of RA patients.
This pilot study is a randomized double blinded, controlled trial. Patients who fulfilled the European League against Rheumatism-American College of Rheumatology (EULAR-ACR) criteria for RA were assigned to receive curcumin or placebo for 12 weeks. The outcomes of this study were comparison of changes in mean value of Disease Activity Score of 28 joints erythrocyte sedimentation rate (DAS28-ESR), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), frequency of T helper 1 and T helper 2 cells population.
From 150 RA patients who were assessed for eligibility, data from 30 patients (15 patients in each group) were analyzed. There was no significant difference between the two groups regarding age ( = 0.6441) and body mass index (BMI, = 0.6016). Our measurement showed a statistically significant reduction in ESR ( < 0.0001), CRP ( < 0.0001) and a non-significant decrease in DAS28-ESR ( = 0.5125) in the curcumin group. Also, the Th1/Th2 ratio favorably decreased in the curcumin group. This finding was due to a significant increase in Th2 cells ( < 0.0001) and a nonsignificant decrease in Th1 cells ( = 0.1532).
Our trial findings revealed the immunomodulatory effects of curcumin. It could be used and recommended as adjunctive treatment for RA patients.
类风湿关节炎（RA）是一种广为人知的全身性自身免疫性炎症疾病。本研究旨在评估新型纳米胶束姜黄素（Sina-姜黄素）对RA患者免疫系统反应的影响。
本初步研究为一项随机双盲对照试验。符合欧洲抗风湿病联盟-美国风湿病学会（EULAR-ACR）RA标准的患者被分配接受姜黄素或安慰剂治疗12周。本研究的结果是比较28个关节疾病活动评分红细胞沉降率（DAS28-ESR）、红细胞沉降率（ESR）、C反应蛋白（CRP）的平均值变化，以及辅助性T细胞1和辅助性T细胞2细胞群体的频率。
在150名接受资格评估的RA患者中，分析了30名患者（每组15名患者）的数据。两组在年龄（P = 0.6441）和体重指数（BMI，P = 0.6016）方面无显著差异。我们的测量显示，姜黄素组的ESR（P < 0.0001）、CRP（P < 0.0001）有统计学显著降低，DAS28-ESR有非显著下降（P = 0.5125）。此外，姜黄素组的Th1/Th2比值呈有利下降。这一发现是由于Th2细胞显著增加（P < 0.0001）和Th1细胞非显著减少（P = 0.1532）。
我们的试验结果揭示了姜黄素的免疫调节作用。它可作为RA患者的辅助治疗方法使用并推荐。
