Zheng Long, Chang Ruibai, Liang Bingjing, Wang Yitong, Zhu Yushan, Jia Zijing, Fan Jindian, Zhang Zhe, Du Bo, Kong Dexin
College of Chinese medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Tianjin Key Laboratory of Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmaceutical Sciences; Tianjin Medical University, Tianjin 300070, China.
Cancer Drug Resist. 2024 Dec 12;7:50. doi: 10.20517/cdr.2024.107. eCollection 2024.
Drug resistance is a major challenge in cancer therapy that often leads to treatment failure and disease relapse. Despite advancements in chemotherapeutic agents and targeted therapies, cancers often develop drug resistance, making these treatments ineffective. Extracellular vesicles (EVs) have gained attention for their potential applications in drug delivery because of their natural origin, biocompatibility, and ability to cross biological barriers. Using the unique properties of EVs could enhance drug accumulation at target sites, minimize systemic toxicity, and precisely target specific cells. Here, we discuss the characteristics and functionalization of EVs, the mechanisms of drug resistance, and the applications of engineered EVs to overcome drug resistance. This review provides a comprehensive overview of the advancements in EV-based drug delivery systems and their applications in overcoming cancer drug resistance. We highlight the potential of EV-based drug delivery systems to revolutionize cancer therapy and offer promising strategies for more effective treatment modalities.
耐药性是癌症治疗中的一项重大挑战，常常导致治疗失败和疾病复发。尽管化疗药物和靶向治疗取得了进展，但癌症往往会产生耐药性，使这些治疗方法失效。细胞外囊泡（EVs）因其天然来源、生物相容性以及跨越生物屏障的能力，在药物递送方面的潜在应用受到了关注。利用细胞外囊泡的独特特性可以增强药物在靶位点的积累，将全身毒性降至最低，并精确靶向特定细胞。在此，我们讨论细胞外囊泡的特征与功能化、耐药机制以及工程化细胞外囊泡在克服耐药性方面的应用。本综述全面概述了基于细胞外囊泡的药物递送系统的进展及其在克服癌症耐药性方面的应用。我们强调基于细胞外囊泡的药物递送系统有可能彻底改变癌症治疗，并为更有效的治疗方式提供有前景的策略。
