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本文引用的文献

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Rejuvenating aged osteoprogenitors for bone repair.使衰老的骨祖细胞恢复活力以促进骨修复。
Elife. 2024 Dec 18;13:RP104068. doi: 10.7554/eLife.104068.
2
The Association between Skull Bone Fractures and the Mortality Outcomes of Patients with Traumatic Brain Injury.颅骨骨折与创伤性脑损伤患者死亡率结局之间的关联。
Emerg Med Int. 2022 Jun 7;2022:1296590. doi: 10.1155/2022/1296590. eCollection 2022.
3
Nutrition, longevity and disease: From molecular mechanisms to interventions.营养、长寿与疾病：从分子机制到干预措施。
Cell. 2022 Apr 28;185(9):1455-1470. doi: 10.1016/j.cell.2022.04.002.
4
A decrease in NAD contributes to the loss of osteoprogenitors and bone mass with aging.随着年龄增长，烟酰胺腺嘌呤二核苷酸（NAD）水平的降低会导致骨祖细胞数量减少和骨量流失。
NPJ Aging Mech Dis. 2021 Apr 1;7(1):8. doi: 10.1038/s41514-021-00058-7.
5
Head injury in the elderly - an overview for the physician.老年人头部损伤 - 医生概述。
Clin Med (Lond). 2019 Mar;19(2):177-184. doi: 10.7861/clinmedicine.19-2-177.
6
Muscle and Bone Mass Loss in the Elderly Population: Advances in diagnosis and treatment.老年人群的肌肉和骨质流失：诊断与治疗进展
J Biomed (Syd). 2018;3:40-49. doi: 10.7150/jbm.23390.
7
Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension.短期间歇性禁食可促进长期肠道健康和 TOR 非依赖性寿命延长。
Curr Biol. 2018 Jun 4;28(11):1714-1724.e4. doi: 10.1016/j.cub.2018.04.015. Epub 2018 May 17.
8
Effects of Aging on Fracture Healing.衰老对骨折愈合的影响。
Curr Osteoporos Rep. 2017 Dec;15(6):601-608. doi: 10.1007/s11914-017-0413-9.
9
Men and mice: Relating their ages.人类和老鼠：年龄相关。
Life Sci. 2016 May 1;152:244-8. doi: 10.1016/j.lfs.2015.10.025. Epub 2015 Oct 24.
10
Facial injuries in automobile crashes.汽车碰撞事故中的面部损伤。
J Oral Maxillofac Surg. 1983 Apr;41(4):241-4. doi: 10.1016/0278-2391(83)90266-5.

恢复骨愈合潜能。

Restoring bone healing potential.

作者信息

Sequeira Inês

机构信息

Centre for Oral Immunobiology and Regenerative Medicine, Institute of Dentistry, Queen Mary University of London, London, United Kingdom.

Barts Centre for Squamous Cancer, Queen Mary University of London, London, United Kingdom.

出版信息

Elife. 2025 Jan 13;14:e105420. doi: 10.7554/eLife.105420.

DOI:10.7554/eLife.105420
PMID:39804692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11729341/
Abstract

A combination of intermittent fasting and administering Wnt3a proteins to a bone injury can rejuvenate bone repair in aged mice.

摘要

间歇性禁食与向骨损伤部位施用Wnt3a蛋白相结合，可以使老年小鼠的骨修复恢复活力。