Guan Xiuju, Li Haitao, Zhang Lijuan, Zhi Hongwei
School of Graduate Studies, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, Shandong, People's Republic of China.
Inflamm Res. 2025 Jan 13;74(1):18. doi: 10.1007/s00011-025-01993-x.
Cardiovascular diseases (CVDs) continue to be a substantial global healthcare burden despite considerable progress in therapies. The inflammatory response during the progression of CVD has attracted considerable attention. Mitochondria serve as the principal energy source for the heart. In cardiovascular illnesses, mitochondrial homeostasis is disrupted, accompanied by structural and functional impairments. During mitochondrial stress or injury, mitochondrial damage-associated molecular patterns (mtDAMPs), such as mitochondrial DNA, cardiolipin, N-formyl peptide, and adenosine triphosphate, are released to activate pattern recognition receptors and trigger immunological responses. Inflammatory responses mediated by mtDAMPs substantially contribute to the pathophysiology of cardiovascular illnesses. In this review, we discuss the molecular mechanisms by which different mtDAMPs control the inflammatory response, address the pathological consequences of mtDAMPs in inducing or exacerbating the inflammatory response in CVDs, and summarize potential therapeutic targets in relevant experimental studies. Preventing or reducing mtDAMP release may play a role in CVD progression by alleviating the inflammatory response.
尽管在治疗方面取得了显著进展，但心血管疾病（CVDs）仍然是全球医疗保健的重大负担。CVD进展过程中的炎症反应已引起广泛关注。线粒体是心脏的主要能量来源。在心血管疾病中，线粒体稳态被破坏，同时伴有结构和功能损伤。在线粒体应激或损伤期间，线粒体损伤相关分子模式（mtDAMPs），如线粒体DNA、心磷脂、N-甲酰肽和三磷酸腺苷被释放，以激活模式识别受体并触发免疫反应。由mtDAMPs介导的炎症反应在很大程度上促进了心血管疾病的病理生理过程。在这篇综述中，我们讨论了不同mtDAMPs控制炎症反应的分子机制，阐述了mtDAMPs在诱导或加剧CVDs炎症反应中的病理后果，并总结了相关实验研究中的潜在治疗靶点。预防或减少mtDAMP释放可能通过减轻炎症反应在CVD进展中发挥作用。
