Noor Adil, Ahmad Nisar, Ali Amjad, Ali Musarat, Iqbal Majid, Khan Muhammad Nauman, Laila Marzia Batool, Shah Syed Nasar, Kaplan Alevcan, Ercişli Sezai, Elshikh Mohamed Soliman
Department of Botany, Kohat University of Science and Technology, Kohat, Pakistan.
Science Laboratory, Government Higher Secondary School, Doaba, Pakistan.
J Basic Microbiol. 2025 Apr;65(4):e2400543. doi: 10.1002/jobm.202400543. Epub 2025 Jan 14.
One of the main difficulties in nanotechnology is the development of an environmentally friendly, successful method of producing nanoparticles from biological sources. Silver-doped zinc oxide nanoparticles (Ag-ZnO NPs), with antibacterial and antioxidant properties, were produced using Adiantum venustum extract as a green technique. Fresh A. venustum plants were gathered, then their bioactive elements were extracted with cold water and processed into nanoparticles. The main goal was to develop Ag-ZnO NPs (nanoparticles) for medical applications, especially with regard to their antifungal and antibacterial properties. Pathogens such as Fusarium oxysporum, Escherichia coli, and Staphylococcus aureus were tested against the synthesized nanoparticles. While FTIR spectroscopy revealed functional groups, X-ray diffraction validated the crystalline structure. The scanning electron microscope analysis revealed that the Ag-ZnO NPs had an average size of 30.16 nm and an irregular shape. Additionally, energy dispersive X-ray analysis) confirmed the elemental composition. The bioactive compounds present in A. venustum significantly stabilized the nanoparticles. Strong antioxidant and antibacterial activity of the Ag-ZnO nanoparticles was demonstrated. In particular, this work shows that the Ag-ZnO nanoparticles produced by green synthesis could be used in biomedical drug delivery and therapy.
纳米技术的主要困难之一是开发一种环境友好、成功的从生物源生产纳米颗粒的方法。利用铁线蕨提取物作为绿色技术制备了具有抗菌和抗氧化性能的银掺杂氧化锌纳米颗粒(Ag-ZnO NPs)。采集新鲜的铁线蕨植物,然后用冷水提取其生物活性成分并加工成纳米颗粒。主要目标是开发用于医学应用的Ag-ZnO NPs(纳米颗粒),特别是考虑到它们的抗真菌和抗菌特性。对尖孢镰刀菌、大肠杆菌和金黄色葡萄球菌等病原体进行了针对合成纳米颗粒的测试。傅里叶变换红外光谱(FTIR)揭示了官能团,X射线衍射验证了晶体结构。扫描电子显微镜分析表明,Ag-ZnO NPs的平均尺寸为30.16nm,形状不规则。此外,能量色散X射线分析(EDX)证实了元素组成。铁线蕨中存在的生物活性化合物显著稳定了纳米颗粒。证明了Ag-ZnO纳米颗粒具有强大的抗氧化和抗菌活性。特别是,这项工作表明通过绿色合成制备的Ag-ZnO纳米颗粒可用于生物医学药物递送和治疗。