Wang Mengxuan, Wang Shuo, Yuan Guoshan, Gao Mingzhou, Wang Jieqiong, Chu Zhenhan, Ren Lv-Ning, Gao Dongmei
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
College of Medical Information Engineering, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
Medicine (Baltimore). 2024 Nov 22;103(47):e40548. doi: 10.1097/MD.0000000000040548.
Investigations have indicated that there is a correlation between thyroid nodules and patients'negative emotions. Nevertheless, the risk factors contributing to the development of negative emotions in thyroid nodule patients remain unidentified. This cross-sectional study recruited 150 patients diagnosed with thyroid nodules through ultrasound examination from January 2022 to January 2023 at Jinan Central Hospital, the Second Affiliated Hospital of Shandong First Medical University, and Qingyun County Maternal and Child Health Hospital as the case group, which were categorized based on their levels of anxiety and depression. Simultaneously, 150 individuals with normal thyroid ultrasound findings were selected as the control group. The researchers chose a self-administered general information questionnaire and 6 psychological scales as the assessment tools for the patients. SPSS 26.0 was used to analyze the risk factors for negative emotions in patients with thyroid nodules. The scores of the self-rating anxiety scale were higher in the case group than in the control group (40.90 ± 9.490 vs 38.37 ± 6.836, P = .028), as were the scores of the self-rating depression scale (44.35 ± 9.180 vs 41.48 ± 8.297, P = .004). There is a positive correlation between thyroid nodules and degrees of anxiety and depression (R = 0.176, P = .002; R = 0.206, P = .000). The results of the binary logistic regression analysis revealed that both fatigue state (P = .013) and negative life events (P = .001) exerted independent effects on anxiety, whereas negative life events (P = .002) had independent effects on depression. This study enhances the understanding of the relationship between thyroid nodules and anxiety and depression. It reveals that thyroid nodules are associated with negative emotions and that negative life events have a significant influence on anxiety and depression in these individuals, which may contribute to the development of strategies for preventing and treating thyroid nodules in clinical practice.
调查表明，甲状腺结节与患者的负面情绪之间存在关联。然而，导致甲状腺结节患者产生负面情绪的风险因素仍不明确。本横断面研究选取了2022年1月至2023年1月期间在山东第一医科大学第二附属医院济南中心医院和庆云县妇幼保健院通过超声检查确诊为甲状腺结节的150例患者作为病例组，并根据其焦虑和抑郁水平进行分类。同时，选取150例甲状腺超声检查结果正常的个体作为对照组。研究人员选择了一份自填式一般信息问卷和6种心理量表作为患者的评估工具。使用SPSS 26.0分析甲状腺结节患者负面情绪的风险因素。病例组的自评焦虑量表得分高于对照组（40.90±9.490对38.37±6.836，P = 0.028），自评抑郁量表得分也是如此（44.35±9.180对41.48±8.297，P = 0.004）。甲状腺结节与焦虑和抑郁程度呈正相关（R = 0.176，P = 0.002；R = 0.206，P = 0.000）。二元逻辑回归分析结果显示，疲劳状态（P = 0.013）和负面生活事件（P = 0.001）对焦虑均有独立影响，而负面生活事件（P = 0.002）对抑郁有独立影响。本研究增进了对甲状腺结节与焦虑和抑郁之间关系的理解。它揭示了甲状腺结节与负面情绪相关，且负面生活事件对这些个体的焦虑和抑郁有显著影响，这可能有助于在临床实践中制定预防和治疗甲状腺结节的策略。
