眼肌型重症肌无力：哪些因素可预测疾病继发全身化？ - Suppr

Ocular Myasthenia gravis: what predicts secondary generalization?

作者信息

Panda Prateek Kumar, Sharawat Indar Kumar

机构信息

Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, 249203, Uttarakhand, India.

出版信息

Acta Neurol Belg. 2025 Jun;125(3):859-860. doi: 10.1007/s13760-025-02720-3. Epub 2025 Jan 15.

DOI:10.1007/s13760-025-02720-3

PMID:39809950

Abstract

摘要

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Ocular Myasthenia gravis: what predicts secondary generalization?眼肌型重症肌无力：哪些因素可预测疾病继发全身化？

Acta Neurol Belg. 2025 Jun;125(3):859-860. doi: 10.1007/s13760-025-02720-3. Epub 2025 Jan 15.

Generalization after ocular onset in myasthenia gravis: a case series in Germany.眼肌型重症肌无力发病后的泛化：德国的一项病例系列研究。

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Thymectomy in ocular myasthenia gravis before generalization results in a higher remission rate.在全身症状出现之前对眼肌型重症肌无力患者进行胸腺切除术可获得更高的缓解率。

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Risk for generalization in ocular onset myasthenia gravis: experience from a neuro-ophthalmology clinic.眼肌型重症肌无力的病情泛化风险：来自神经眼科诊所的经验

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Clinical predictors for the prognosis of myasthenia gravis.重症肌无力预后的临床预测因素

BMC Neurol. 2017 Apr 19;17(1):77. doi: 10.1186/s12883-017-0857-7.

Prediction of the generalization of myasthenia gravis with purely ocular symptoms at onset: a multivariable model development and validation.发病时仅有眼肌症状的重症肌无力的病情进展预测：多变量模型的建立与验证

Ther Adv Neurol Disord. 2022 Jun 21;15:17562864221104508. doi: 10.1177/17562864221104508. eCollection 2022.

Thymectomy and Risk of Generalization in Patients with Ocular Myasthenia Gravis: A Multicenter Retrospective Cohort Study.胸腺瘤切除术和眼肌型重症肌无力患者泛化的风险：一项多中心回顾性队列研究。

Neurotherapeutics. 2021 Oct;18(4):2449-2457. doi: 10.1007/s13311-021-01129-z. Epub 2021 Oct 8.

Immunotherapy of ocular myasthenia gravis reduces conversion to generalized myasthenia gravis.眼肌型重症肌无力的免疫疗法可降低其转化为全身型重症肌无力的几率。

J Neuroophthalmol. 2003 Dec;23(4):251-5. doi: 10.1097/00041327-200312000-00002.

Association of immunosuppression treatment with generalization among patients with ocular myasthenia gravis: A propensity score analysis.眼肌型重症肌无力患者免疫抑制治疗与病情泛化的关联：一项倾向评分分析。

Eur J Neurol. 2022 Jun;29(6):1805-1814. doi: 10.1111/ene.15292. Epub 2022 Mar 7.

Lack of Immunotherapy as the Only Predictor of Secondary Generalization in Very-Late-Onset Myasthenia Gravis With Pure Ocular Onset.缺乏免疫治疗是单纯眼肌型极晚发型重症肌无力继发全身型的唯一预测因素。

Front Neurol. 2022 Apr 25;13:857402. doi: 10.3389/fneur.2022.857402. eCollection 2022.

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Assessing Performance and Clinical Usefulness in Prediction Models With Survival Outcomes: Practical Guidance for Cox Proportional Hazards Models.评估生存结局预测模型的性能和临床实用性：Cox 比例风险模型的实用指南。

Ann Intern Med. 2023 Jan;176(1):105-114. doi: 10.7326/M22-0844. Epub 2022 Dec 27.

Understanding the Symptom Burden and Impact of Myasthenia Gravis from the Patient's Perspective: A Qualitative Study.从患者角度理解重症肌无力的症状负担及影响：一项定性研究

Neurol Ther. 2023 Feb;12(1):107-128. doi: 10.1007/s40120-022-00408-x. Epub 2022 Nov 2.

Risk Factors for Generalization in Patients with Ocular Myasthenia Gravis: A Multicenter Retrospective Cohort Study.眼肌型重症肌无力患者病情泛化的危险因素：一项多中心回顾性队列研究。

Neurol Ther. 2022 Mar;11(1):73-86. doi: 10.1007/s40120-021-00292-x. Epub 2021 Nov 2.

Preliminary Findings of a Dedicated Ocular Myasthenia Gravis Rating Scale: The OMGRate.一种专门的重症肌无力眼部评定量表（OMGRate）的初步研究结果。

Neuroophthalmology. 2019 Oct 9;44(3):148-156. doi: 10.1080/01658107.2019.1660686. eCollection 2020 Jun.

Factors associated with acute exacerbations of myasthenia gravis.与重症肌无力急性恶化相关的因素。

Muscle Nerve. 2019 Dec;60(6):693-699. doi: 10.1002/mus.26689. Epub 2019 Sep 10.

Ocular Myasthenia Gravis: Toward a Risk of Generalization Score and Sample Size Calculation for a Randomized Controlled Trial of Disease Modification.眼肌型重症肌无力：迈向疾病修饰随机对照试验的病情泛化风险评分与样本量计算

J Neuroophthalmol. 2016 Sep;36(3):252-8. doi: 10.1097/WNO.0000000000000350.

Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): the TRIPOD statement.透明报告个体预后或诊断的多变量预测模型（TRIPOD）：TRIPOD 声明。

Ann Intern Med. 2015 Jan 6;162(1):55-63. doi: 10.7326/M14-0697.

Chemical-shift and diffusion-weighted magnetic resonance imaging of thymus in myasthenia gravis: usefulness of quantitative assessment.重症肌无力患者胸腺的化学位移和扩散加权磁共振成像：定量评估的效用

Invest Radiol. 2015 Apr;50(4):228-38. doi: 10.1097/RLI.0000000000000120.

The bootstrap: a technique for data-driven statistics. Using computer-intensive analyses to explore experimental data.自助法：一种数据驱动统计的技术。利用计算机密集型分析来探索实验数据。

Clin Chim Acta. 2005 Sep;359(1-2):1-26. doi: 10.1016/j.cccn.2005.04.002.

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Ocular Myasthenia gravis: what predicts secondary generalization?

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