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生姜及其组合对大鼠实验性诱导糖尿病肾病的可能改善作用：组织学和免疫组织化学研究

The Possible Ameliorative Effect of , Ginger, and Their Combination on Experimentally Induced Diabetic Nephropathy in a Rat Model: Histological and Immunohistochemical Study.

作者信息

Elsayed Hoda M, Abdel-Aziz Hekmat Osman, Ahmed Ghada Mohammed, Adly Mohamed Arafa, Mohammed Sherine Ahmed

机构信息

Department of Histology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Department of Zoology, Faculty of Science, Sohag University, Sohag, Egypt.

出版信息

J Microsc Ultrastruct. 2023 Jan 11;12(4):199-210. doi: 10.4103/jmau.jmau_62_22. eCollection 2024 Oct-Dec.

DOI:10.4103/jmau.jmau_62_22
PMID:39811596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11729022/
Abstract

BACKGROUND

Diabetes represents a chronic disease characterized by hyperglycemia. Several changes in the renal functions had been detected in diabetic patients.

AIM OF THE WORK

This study was conducted to compare the possible ameliorative role of both ginger and either alone or in combination upon experimentally induced diabetic nephropathy.

MATERIALS AND METHODS

Sixty adult male albino rats were used in this study. Rats were divided into three groups. Control (group I) included 20 rats. Diabetic group (group II) included 10 rats. Group III included 30 rats subdivided into three subgroups 10 animals each: Subgroup IIIa diabetic treated with 100 mg/kg for 30 days. Subgroup IIIb diabetic treated with 400 mg/kg ginger for 30 days orally. Subgroup IIIc diabetic treated with both 100 mg/kg and 400 mg/kg ginger for 30 days orally. Hemotoxylin and eosin staining, Periodic acid Schiff and Masson trichrome were done. Ultrastructural examination was done. Immunohistochemical markers used were caspase-3 for apoptosis and CD68 for macrophages. Morphometric and statistical analyses were done.

RESULTS

Diabetes caused a significant increase in collagen fibers in the renal cortex, the caspase-3 expression as well as the number of macrophages. Ultrastructurally, there was an irregularly thickened glomerular basement membrane and effacement of podocytes. Ginger treatment alone or in combination with exhibited more pronounced improvement of diabetes-induced degenerative changes and a significant decrease in collagen fibers, the caspase-3 expression as well as the number of macrophages compared to alone.

CONCLUSION

Ginger treatment alone or in combination with exhibited more pronounced improvement in diabetes nephropathy.

摘要

背景

糖尿病是一种以高血糖为特征的慢性疾病。在糖尿病患者中已检测到肾功能的若干变化。

工作目的

本研究旨在比较生姜单独或联合使用对实验性诱导的糖尿病肾病可能的改善作用。

材料与方法

本研究使用了60只成年雄性白化大鼠。大鼠分为三组。对照组（第一组）包括20只大鼠。糖尿病组（第二组）包括10只大鼠。第三组包括30只大鼠，再细分为三个亚组，每组10只动物：亚组IIIa为糖尿病大鼠，用100毫克/千克治疗30天。亚组IIIb为糖尿病大鼠，口服400毫克/千克生姜30天。亚组IIIc为糖尿病大鼠，口服100毫克/千克和400毫克/千克生姜30天。进行苏木精和伊红染色、过碘酸希夫染色和马松三色染色。进行超微结构检查。使用的免疫组织化学标记物为用于凋亡的半胱天冬酶 - 3和用于巨噬细胞的CD68。进行形态计量学和统计学分析。

结果

糖尿病导致肾皮质胶原纤维显著增加、半胱天冬酶 - 3表达以及巨噬细胞数量增加。在超微结构上，肾小球基底膜不规则增厚且足细胞消失。与单独使用相比，单独使用生姜或与联合使用对糖尿病诱导的退行性变化有更明显的改善，胶原纤维、半胱天冬酶 - 3表达以及巨噬细胞数量显著减少。

结论

单独使用生姜或与联合使用对糖尿病肾病有更明显的改善。

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