Eleazu C O, Iroaganachi M, Okafor P N, Ijeh I I, Eleazu K C
Department of Biochemistry, National Root Crops Research Institute, Umudike, Nigeria;
Int J Biomed Sci. 2013 Jun;9(2):82-90.
The ameliorating potentials of ginger incorporated feed (10%) on the relative organ weights of Streptozotocin (STZ) induced diabetic rats was investigated. The experiment lasted for three weeks. Results show that administration of 10% ginger feed to the diabetic rats of group 3, resulted in a 29.81% decrease in their resulting hyperglycemia with a corresponding amelioration of elevated urinary protein, sugars, specific gravity as well as renal growth. In addition, administration of the ginger incorporated feeds to the diabetic rats of group 3, resulted in 9.88% increase in body weight with a corresponding 60.24% increase in growth compared with the non-diabetic rats administered standard rat pellets that had 6.21% increase in weight with a corresponding 60.14% increase in growth unlike the diabetic control rats that recorded 28.62% decrease in body weight with a corresponding 239.9% decrease in growth rates. Analysis of the chemical composition of the flour of the ginger incorporated feed indicated that it contained moderate amounts of moisture, crude fibre, alkaloids, saponins, tannins, Fe and Zn but considerable amounts of proteins, lipids, carbohydrates, ash, flavonoids, calcium, magnesium, potassium, phosphorous and energy value. There was no significant difference (P>0.05) in the liver and relative liver weights of the diabetic control rats and the diabetic -ginger treated rats. In addition, there were no significant differences in the kidney weights of the non-diabetic, diabetic control and diabetic treated rats (P>0.05) while there were significant differences in the relative kidney weights of the non-diabetic rats and the diabetic rats treated with ginger feeds (P<0.05). Results show that the use of ginger in the dietary management of diabetes mellitus could be a breakthrough in the search for novel plants that could prevent the development of diabetic glomerular hypertrophy.
研究了含10%生姜的饲料对链脲佐菌素（STZ）诱导的糖尿病大鼠相对器官重量的改善潜力。实验持续了三周。结果表明，给第3组糖尿病大鼠喂食10%生姜饲料后，其血糖水平降低了29.81%，同时尿蛋白、尿糖、尿比重升高以及肾脏生长的情况也相应得到改善。此外，给第3组糖尿病大鼠喂食含生姜的饲料后，其体重增加了9.88%，生长率相应增加了60.24%；而喂食标准大鼠颗粒饲料的非糖尿病大鼠体重增加了6.21%，生长率相应增加了60.14%；糖尿病对照大鼠体重下降了28.62%，生长率相应下降了239.9%。对含生姜饲料面粉的化学成分分析表明，其含有适量的水分、粗纤维、生物碱、皂苷、单宁、铁和锌，但含有大量的蛋白质、脂质、碳水化合物、灰分、黄酮类化合物、钙、镁、钾、磷和能量值。糖尿病对照大鼠和经生姜治疗的糖尿病大鼠的肝脏及相对肝脏重量无显著差异（P>0.05）。此外，非糖尿病大鼠、糖尿病对照大鼠和经生姜治疗的糖尿病大鼠的肾脏重量无显著差异（P>0.05），而喂食生姜饲料的非糖尿病大鼠和糖尿病大鼠的相对肾脏重量有显著差异（P<0.05）。结果表明，在糖尿病饮食管理中使用生姜可能是寻找可预防糖尿病肾小球肥大发展的新型植物方面的一个突破。
