Pasa Chusairil, Pamungkasari Eti P, Doewes Muchsin, Purwanto Bambang, Hartono Hartono, Cilmiaty Risya, Dirgahayu Paramasari
Doctoral Program of Medical Science, Faculty of Medicine, Universitas Sebelas Maret Surakarta, Indonesia.
Department of Public Health, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia.
Narra J. 2024 Dec;4(3):e1321. doi: 10.52225/narra.v4i3.1321. Epub 2024 Oct 31.
Osteoporosis increases fracture risk and reduces quality of life in menopausal women. Although physical activity, such as walking and bone joint exercise, is known to help maintain bone health, its effectiveness needs further examination. The aim of this study was to analyze the effects of physical activity, in particular walking and bone joint exercise, on enhancing bone remodeling in menopausal women. A randomized controlled trial was conducted among menopausal women and allocated into three groups: walking, bone joint exercise, and control groups. The intervention was provided for eight weeks, with the outcomes measured before and after the intervention. The study assessed five bone remodeling biomarkers: estrogen, parathyroid hormone (PTH), receptor activator of nuclear factor kappa-β ligand (RANKL), tumor necrosis factor-alpha (TNF-α), and bone mineral density (BMD). The paired sample student t-test and ANOVA were used to assess the effects of the interventions. The results indicated that, compared to pre-intervention, both walking and bone joint exercise significantly increased the estrogen ( = 0.026 and 0.023, respectively), decreased RANKL ( 0.019 and 0.002, respectively), decreased PTH levels ( = 0.022 and 0.048, respectively) and increased the BMD scores ( 0.001 and < 0.001, respectively). In the control group, none of the remodeling biomarkers significantly changed except the mean level of TNF-α, which was increased significantly ( 0.001). This study highlights that structured exercise, such as walking and bone joint exercise, can significantly enhance bone remodeling markers in menopausal women. Therefore, implementing such physical activities into management may provide benefits to menopausal women.
骨质疏松症会增加绝经后女性的骨折风险并降低其生活质量。尽管诸如散步和关节运动等体育活动有助于维持骨骼健康，但仍需进一步研究其有效性。本研究旨在分析体育活动，尤其是散步和关节运动，对促进绝经后女性骨重塑的影响。对绝经后女性进行了一项随机对照试验，并将她们分为三组：散步组、关节运动组和对照组。干预为期八周，并在干预前后测量结果。该研究评估了五种骨重塑生物标志物：雌激素、甲状旁腺激素（PTH）、核因子κ-β受体激活剂配体（RANKL）、肿瘤坏死因子-α（TNF-α）和骨密度（BMD）。采用配对样本t检验和方差分析来评估干预效果。结果表明，与干预前相比，散步和关节运动均显著增加了雌激素水平（分别为=0.026和=0.023），降低了RANKL水平（分别为<0.019和<0.002），降低了PTH水平（分别为=0.022和=0.048），并提高了骨密度评分（分别为=0.001和<0.001）。在对照组中，除TNF-α平均水平显著升高（<0.001）外，其他重塑生物标志物均无显著变化。本研究强调，诸如散步和关节运动等有组织的运动可显著增强绝经后女性的骨重塑标志物。因此，将此类体育活动纳入管理可能会给绝经后女性带来益处。
