植物来源的类外泌体纳米颗粒在组织修复与再生中的作用

Plant-derived exosome-like nanoparticles in tissue repair and regeneration.

作者信息

Gao Canyu, Chen Yang, Wen Xingyue, Han Ruiying, Qin Yuxiang, Li Sijie, Tang Rong, Zhou Weikai, Zhao Junyu, Sun Jianxun, Li Zhengyong, Tan Zhen, Wang Deli, Zhou Changchun

机构信息

College of Biomedical Engineering, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China.

Center of Medical Product Technical Inspection, Chengdu, 610015, China.

出版信息

J Mater Chem B. 2025 Feb 12;13(7):2254-2271. doi: 10.1039/d4tb02394c.

DOI:10.1039/d4tb02394c

PMID:39817682

Abstract

This article reviews plant-derived exosome-like nanoparticles (ELNs), and highlights their potential in regenerative medicine. Various extraction techniques, including ultracentrifugation and ultrafiltration, and their impact on ELN purity and yield were discussed. Characterization methods such as microscopy and particle analysis are found to play crucial roles in defining ELN properties. This review is focused on exploring the therapeutic potential of ELNs in tissue repair, immune regulation, and antioxidant activities. Further research and optimization methods for extraction of ELNs to realize clinical potential applications are necessary.

摘要

本文综述了植物来源的外泌体样纳米颗粒（ELNs），并强调了它们在再生医学中的潜力。讨论了包括超速离心和超滤在内的各种提取技术，以及它们对ELN纯度和产量的影响。发现诸如显微镜检查和颗粒分析等表征方法在定义ELN特性方面起着关键作用。本综述着重探讨ELNs在组织修复、免疫调节和抗氧化活性方面的治疗潜力。有必要进一步研究和优化ELNs的提取方法，以实现其临床潜在应用。