AbuBakar Nabila, Behnke Jerzy M, Sahimin Norhidayu, Kang Xiaoye, Mohd Shahar Siti Nursyahirah, Lim Yvonne Ai Lian, Mohd Zain Siti Nursheena
Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia.
School of Life Sciences, University of Nottingham, University Park, Nottingham, United Kingdom.
PLoS One. 2025 Jan 16;20(1):e0317349. doi: 10.1371/journal.pone.0317349. eCollection 2025.
Dengue remains the most rapidly advancing vector-borne disease in the world, and while the disease burden is predominantly in low-to-middle-income countries, the association with poverty remains in question. Consequently, a study was undertaken to evaluate the prevalence of anti-dengue antibodies among individuals residing in the People's Housing Program (PPR), a government-sponsored low-cost housing initiative targeting low-income earners. This type of public housing often faces challenges, including substandard housing facilities. Therefore this study took into consideration several social determinants of health, including the economic, environmental, and social conditions that contribute towards dengue transmission. The research was conducted over a period of 18 months across 14 PPRs in Klang Valley, Malaysia. Overall seroprevalence of anti-dengue immunoglobulin G (IgG) was 78.2% (CL: 72.5-83.1) among the 436 residents who participated in the study, while seroprevalence of anti-dengue IgM was 0.9% (CL: 0.2-3.2). Log-linear statistical models with the presence/absence of anti-dengue IgG and individual factors showed significant associations of anti-dengue IgG with age, income, location, and waste bin conditions, but ethnicity was just at the wrong side of the cut-off for significance. However, a multifactorial model, in which all relevant factors were taken into account, showed that location and ethnicity were the key risk factors. For anti-dengue IgM, the only significant association was with the presence of stagnant water bodies around the compounds. Findings from this study highlight an acute need for improvements in the environmental and societal health of those residing in PPRs in locations that are particularly at risk, and continuous community empowerment to ensure that the preventive measures taken to eradicate dengue are locally sustainable.
登革热仍然是全球传播速度最快的媒介传播疾病。虽然疾病负担主要集中在低收入和中等收入国家，但与贫困之间的关联仍存疑问。因此，开展了一项研究，以评估居住在人民住房计划（PPR）中的个人体内抗登革热抗体的流行情况。人民住房计划是一项由政府资助的面向低收入者的低成本住房倡议。这类公共住房往往面临诸多挑战，包括住房设施不达标准。因此，本研究考虑了若干健康的社会决定因素，包括有助于登革热传播的经济、环境和社会状况。该研究在马来西亚巴生谷的14个人民住房计划项目中进行，为期18个月。在参与研究的436名居民中，抗登革热免疫球蛋白G（IgG）的总体血清阳性率为78.2%（可信区间：72.5 - 83.1），而抗登革热IgM的血清阳性率为0.9%（可信区间：0.2 - 3.2）。带有抗登革热IgG存在与否及个体因素的对数线性统计模型显示，抗登革热IgG与年龄、收入、居住地点和垃圾桶状况存在显著关联，但种族因素仅略低于显著性临界值。然而，一个考虑了所有相关因素的多因素模型表明，居住地点和种族是关键风险因素。对于抗登革热IgM，唯一显著的关联是与小区周围存在积水水体有关。本研究结果凸显了迫切需要改善居住在特别危险地区的人民住房计划项目居民的环境和社会健康状况，并持续增强社区能力，以确保为根除登革热而采取的预防措施在当地具有可持续性。
