Li Yongkai, He Xiaojing, Li Dandan, Yuan Xin, Xu Jun, Yang Jianzhong
Emergency Department, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Department of Obstetrics and Gynaecology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Sci Rep. 2025 Jan 16;15(1):2143. doi: 10.1038/s41598-025-85104-0.
To measure the correlation and agreement between arterial and peripheral venous blood lactate in the emergency room and to assess the predictive value of lactate for the occurrence of cardiac arrest. This was a retrospective cohort study involving 784 patients from January 1, 2020, to July 31, 2021, in the Emergency Room of the First Affiliated Hospital of Xinjiang Medical University. General information, vital signs, clinical symptoms, and laboratory findings of the patient were collected. Linear regression was used to analyze the correlation between arterial and venous blood lactate, Bland-Altman plots were drawn to assess the concordance of (arterial-venous) serum lactate concentrations, and the predictive value of arterial and venous lactate for the occurrence of cardiac arrest was assessed by using the receiver operating characteristic curve (ROC). A total of 784 emergency room patients were included in the study, of whom 384 experienced cardiac arrest and 400 had no cardiac arrest. Arterial and venous lactate univariate linear regression analysis, correlation coefficient r = 0.80, linear equation Y = 0.729 + 0.960*X, and had statistical significance (P < 0.001); arterial blood (lactate) and venous blood (lactate) were -0.548 (95%CI -0.774 ~ -0.322 mmol/L), and the upper and lower limits of the 95% limits of agreement (LoA) were 5.777 (95%CI 5.390 ~ 6.163 mmol/L) and -6.872 (-7.2590 ~ -6.4855 mmol/L), indicating that the consistency of arterial blood lactate and venous blood lactate is poor and statistically significant (P < 0.001). The results of this study show that venous and arterial blood lactate levels are not identical, but are highly correlated and are important predictors of cardiac arrest in emergency room patients.
测量急诊室动脉血与外周静脉血乳酸之间的相关性和一致性，并评估乳酸对心脏骤停发生的预测价值。这是一项回顾性队列研究，纳入了2020年1月1日至2021年7月31日在新疆医科大学第一附属医院急诊科就诊的784例患者。收集患者的一般信息、生命体征、临床症状和实验室检查结果。采用线性回归分析动脉血与静脉血乳酸之间的相关性，绘制Bland-Altman图评估（动脉-静脉）血清乳酸浓度的一致性，并采用受试者工作特征曲线（ROC）评估动脉血和静脉血乳酸对心脏骤停发生的预测价值。本研究共纳入784例急诊患者，其中384例发生心脏骤停，400例未发生心脏骤停。动脉血和静脉血乳酸单因素线性回归分析，相关系数r = 0.80，线性方程Y = 0.729 + 0.960*X，差异有统计学意义（P < 0.001）；动脉血（乳酸）与静脉血（乳酸）差值为-0.548（95%CI -0.774 ~ -0.322 mmol/L），一致性界限（LoA）95%上下限分别为5.777（95%CI 5.39 ~ 6.163 mmol/L）和-6.872（-7.2590 ~ -6.485 mmol/L）,表明动脉血乳酸与静脉血乳酸一致性较差且差异有统计学意义（P < 0.001）。本研究结果表明，静脉血和动脉血乳酸水平虽不相同，但高度相关，是急诊患者心脏骤停的重要预测指标。
