Alomari Omar, Abualkhair Khaled A, Saad Khaled, Magdy Sara, Omran Janna A, AlSanafini Mahmoud M, Hassan Loay A, ElBasatiny Omar Y, Machane Djihane, Abdulrahim Marwan, Abo-Elmaged Hadeer G, Elshaieb Mohamed, Elfarargy Mohamed Shawky, Elhoufey Amira, Dailah Hamad Ghaleb, Sayed Aya H, Ismail Alaa, Walid Bassel, Hashemy Mahmoud, Afifi Ahmed M, Elgenidy Anas
University of Health Sciences, Istanbul, Turkey.
Zagazig University, Zagazig, Egypt.
Pediatr Radiol. 2025 Feb;55(2):215-225. doi: 10.1007/s00247-024-06159-1. Epub 2025 Jan 17.
Endoscopic ultrasound (US) has been established as a safe diagnostic tool for adults, but its use in children remains underexplored. The rising prevalence of pediatric hepato-pancreato-biliary disorders requires a closer examination of its utility. In this systematic review, we aimed to evaluate the efficacy, safety, and clinical impact of endoscopic US in the pediatric population, concentrating on its diagnostic accuracy and therapeutic applications.
All related clinical studies were identified by searching the Web of Science databases, PubMed (MEDLINE), Scopus, Cochrane, and Embase. Data were extracted from relevant studies using a pre-planned Excel sheet.
Twenty-eight studies demonstrated that endoscopic US in children is safe, technically successful, and clinically impactful, offering valuable diagnostic and interventional competencies. Endoscopic US was frequently used for microlithiasis, choledocholithiasis, and pancreaticobiliary anomalies. It reliably outperformed other imaging modalities, effectively reducing the need for more invasive procedures. Endoscopic US had a remarkable clinical impact, with diverse diagnostic yields, highlighting its role in diagnosing and treating children with hepato-pancreato-biliary disorders. The safety profile of endoscopic US in children was excellent, with nominal reported complications.
Our comprehensive review underlines the promising application of endoscopic US in pediatric hepato-pancreato-biliary diseases. The endoscopic US demonstrates its diagnostic accuracy and therapeutic potential in children, offering a non-invasive, safe, and efficient approach. As we move forward, addressing the identified limitations and expanding the pediatric-specific research on endoscopic US will enhance our ability to provide precise and patient-centered care in managing pediatric hepato-pancreato-biliary disorders.
内镜超声已被确立为成人的一种安全诊断工具，但在儿童中的应用仍未得到充分探索。小儿肝胰胆疾病患病率的上升需要更深入地研究其效用。在本系统评价中，我们旨在评估内镜超声在儿科人群中的疗效、安全性和临床影响，重点关注其诊断准确性和治疗应用。
通过检索科学网数据库、PubMed（MEDLINE）、Scopus、Cochrane和Embase来识别所有相关临床研究。使用预先规划的Excel表格从相关研究中提取数据。
28项研究表明，儿童内镜超声是安全的，技术上是成功的，并且具有临床影响，具有重要的诊断和介入能力。内镜超声常用于微结石、胆总管结石和胰胆异常。它可靠地优于其他成像方式，有效减少了对更具侵入性程序的需求。内镜超声具有显著的临床影响，诊断率多样，突出了其在诊断和治疗小儿肝胰胆疾病中的作用。儿童内镜超声的安全性良好，报告的并发症极少。
我们的综合评价强调了内镜超声在小儿肝胰胆疾病中的应用前景。内镜超声在儿童中显示出其诊断准确性和治疗潜力，提供了一种无创、安全且高效的方法。随着我们向前发展，解决已发现的局限性并扩大针对儿童的内镜超声研究将提高我们在管理小儿肝胰胆疾病时提供精准和以患者为中心的护理的能力。
