Cai Dan, Liu Tuoqin, Weng Wei, Zhu Xinhong
Department of Orthopedics, The First People's Hospital of Huzhou, First Affiliated Hospital of Huzhou University, Zhejiang 313000, China.
Intensive Care Unit, People's Hospital of Wuxing District, Wuxing District Maternal and Child Health Hospital, Huzhou, Zhejiang 313000, China.
Biomater Res. 2025 Jan 16;29:0128. doi: 10.34133/bmr.0128. eCollection 2025.
Due to their exceptional cell compatibility, biodegradability, and capacity to trigger tissue regeneration, extracellular matrix (ECM) materials have drawn considerable attention in tissue healing and regenerative medicine. Interestingly, these materials undergo continuous degradation and release antimicrobial peptides (AMPs) while simultaneously promoting tissue regeneration, thereby exerting a potent antibacterial effect. On this basis, a variety of basic properties of ECM materials, such as porous adsorption, hydrophilic adsorption, group crosslinking, and electrostatic crosslinking, can be used to facilitate the integration of ECM materials and antibacterial agents through physical and chemical approaches in order to enhance the antibacterial efficacy. This article reviews the recent advancements in the study of ECM antibacterial materials, including the antibacterial function and antibacterial mechanism of free-standing ECM materials and ECM-based composite materials. In addition, the urgent challenges and future research prospects of ECM materials in the anti-infection industry are discussed.
由于其卓越的细胞相容性、生物可降解性以及触发组织再生的能力，细胞外基质（ECM）材料在组织愈合和再生医学领域引起了广泛关注。有趣的是，这些材料在促进组织再生的同时会持续降解并释放抗菌肽（AMPs），从而发挥强大的抗菌作用。在此基础上，ECM材料的多种基本特性，如多孔吸附、亲水吸附、基团交联和静电交联等，可用于通过物理和化学方法促进ECM材料与抗菌剂的结合，以增强抗菌效果。本文综述了ECM抗菌材料的最新研究进展，包括独立的ECM材料和基于ECM的复合材料的抗菌功能及抗菌机制。此外，还讨论了ECM材料在抗感染领域面临的紧迫挑战和未来的研究前景。
