Li Jing, Tang Zeli, Zhang Xia, Zheng Yanling, Yv Jie
People's Hospital of Honghuagang District, Zunyi, 563000, China.
Guizhou Hospital The First Affiliared Hospital of Sun Yat-Sen Univeruity, Guiyang, China.
Sci Rep. 2025 May 14;15(1):16793. doi: 10.1038/s41598-025-01133-9.
Sarcopenia, characterized by the progressive loss of skeletal muscle mass and strength, significantly impacts the people, leading to increased frailty and mortality. The atherogenic index of plasma (AIP), a biomarker for lipid imbalance, may be linked to sarcopenia due to shared pathways of inflammation and metabolic dysregulation. Data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018 cycles were analyzed. The AIP was calculated as the logarithm of the ratio of triglycerides to High density lipoprotein cholesterol. Sarcopenia was defined using the appendicular skeletal muscle mass index (ASMBMI) adjusted for body mass index (BMI). Multivariable linear regression and logistic regression models were employed to assess the association between AIP and ASMBMI, as well as sarcopenia. Restrictive cubic spline curves were utilized to analyze potential nonlinear associations between AIP and outcome indicators. Additionally, subgroup analyses and intergroup interaction tests were performed. Elevated AIP levels were associated with decreased ASMBMI and an increased risk of sarcopenia. After adjusting for confounding factors, the association between AIP and ASMBMI remained significant (Beta [95% CI] = -0.02 [-0.03, -0.01], P < 0.001). AIP was significantly associated with sarcopenia (OR [95% CI] = 2.6 [1.78, 3.81], P = < 0.001). AIP is significantly associated with reduced muscle mass and potentially with sarcopenia, suggesting that lipid metabolism plays a critical role in muscle health. Identifying AIP as a modifiable risk factor could have important public health implications for managing sarcopenia.
肌肉减少症，其特征为骨骼肌质量和力量的逐渐丧失，对人群有显著影响，导致虚弱和死亡率增加。血浆致动脉粥样硬化指数（AIP）是脂质失衡的生物标志物，由于炎症和代谢失调的共同途径，可能与肌肉减少症有关。对2011 - 2018年国家健康和营养检查调查（NHANES）周期的数据进行了分析。AIP计算为甘油三酯与高密度脂蛋白胆固醇比值的对数。肌肉减少症使用根据体重指数（BMI）调整的四肢骨骼肌质量指数（ASMBMI）来定义。采用多变量线性回归和逻辑回归模型评估AIP与ASMBMI之间的关联以及肌肉减少症。使用限制性立方样条曲线分析AIP与结局指标之间的潜在非线性关联。此外，进行了亚组分析和组间交互检验。AIP水平升高与ASMBMI降低和肌肉减少症风险增加相关。在调整混杂因素后，AIP与ASMBMI之间的关联仍然显著（β[95%CI] = -0.02[-0.03, -0.01]，P < 0.001）。AIP与肌肉减少症显著相关（OR[95%CI] = 2.6[1.78, 3.81]，P = < 0.001）。AIP与肌肉质量降低显著相关，并且可能与肌肉减少症相关，这表明脂质代谢在肌肉健康中起关键作用。将AIP确定为一个可改变的风险因素可能对肌肉减少症的管理具有重要的公共卫生意义。
