Almuqbil Mansour, Alobaid Rama Abdulhamid Mohammed, Alhamad Amouna Abdulrahim Mazal, Eddin Noor Hussam, Yahya Nora Al, Alsanie Walaa F, Alamri Abdulhakeem S, Alhomrani Majid, Alshammary Amal F, Gilkaramenthi Rafiulla, Asdaq Syed Mohammed Basheeruddin
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh, Saudi Arabia.
Cancer Control. 2025 Jan-Dec;32:10732748251313498. doi: 10.1177/10732748251313498.
Cancer patients often face challenges in managing their disease, particularly with regard to contraindications related to medications, foods, and physical activity, which can negatively affect treatment outcomes. This study aimed to evaluate cancer patients' awareness of these contraindications and to explore the influence of sociodemographic factors, support systems, comorbidities, and medication use on their knowledge.
A cross-sectional prospective study was conducted with 125 cancer patients in Saudi Arabia between December 2022 and February 2023. Participants were selected using purposive sampling, and data were collected through a validated questionnaire. Multinomial regression analysis was employed to identify the predictors of awareness of contraindicated medications, foods, and other environmental factors.
Nationality, co-morbidities, and cancer duration were significant predictors of awareness regarding contraindicated drugs. Saudi patients were more likely to be aware of contraindicated medications ( = 0.010), and those without chronic diseases were 15 times more likely to know about drug contraindications (OR = 15.076, 95% CI: 3.442-66.042). Cancer diagnosis ( = 0.033) and cancer duration ( = 0.022) were also significant for food contraindications. Over 58% were unaware of the need to regulate body temperature during treatment. Location influenced exercise awareness ( = 0.064) and complementary and alternative medicine (CAM) awareness, with rural participants showing higher CAM knowledge ( = 0.001).
This study emphasizes the need to improve cancer patients' awareness of contraindications, particularly regarding medications and foods. Key factors influencing awareness include nationality, co-morbidities, and cancer duration. While family support is beneficial, it doesn't directly enhance knowledge, highlighting the importance of targeted educational interventions to improve patient outcomes and safety.
癌症患者在应对疾病过程中常常面临挑战，尤其是在与药物、食物和体育活动相关的禁忌方面，这些可能会对治疗结果产生负面影响。本研究旨在评估癌症患者对这些禁忌的认知，并探讨社会人口学因素、支持系统、合并症和药物使用对其知识水平的影响。
2022年12月至2023年2月期间，对沙特阿拉伯的125名癌症患者进行了一项横断面前瞻性研究。采用目的抽样法选取参与者，并通过一份经过验证的问卷收集数据。采用多项回归分析来确定对禁忌药物、食物和其他环境因素认知的预测因素。
国籍、合并症和癌症病程是禁忌药物认知的显著预测因素。沙特患者更有可能知晓禁忌药物（P = 0.010），而没有慢性病的患者知晓药物禁忌的可能性是其他人的15倍（OR = 15.076，95% CI：3.442 - 66.042）。癌症诊断（P = 0.033）和癌症病程（P = 0.022）对食物禁忌认知也具有显著意义。超过58%的患者不知道在治疗期间需要调节体温。地区影响运动认知（P = 0.064）和补充与替代医学（CAM）认知，农村参与者的CAM知识水平更高（P = 0.001）。
本研究强调有必要提高癌症患者对禁忌的认知，特别是关于药物和食物方面。影响认知的关键因素包括国籍、合并症和癌症病程。虽然家庭支持有益，但并不能直接提高知识水平，这凸显了针对性教育干预对改善患者治疗效果和安全性的重要性。
