Cordisco Estefanía, Serra Diego Omar
Laboratorio de Estructura y Fisiología de Biofilms Microbianos, Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Predio CONICET Rosario, Ocampo y Esmeralda, (2000) Rosario, Argentina.
Laboratorio de Estructura y Fisiología de Biofilms Microbianos, Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Predio CONICET Rosario, Ocampo y Esmeralda, (2000) Rosario, Argentina.
Trends Microbiol. 2025 Apr;33(4):459-471. doi: 10.1016/j.tim.2024.12.011. Epub 2025 Jan 18.
The widespread use of antibiotics to treat bacterial infections has led to the common perception that their only function is to inhibit growth or kill bacteria. However, it has become clear that when antibiotics reach susceptible bacteria at non-lethal concentrations, they perform additional functions that significantly impact bacterial physiology, shaping both individual and collective behaviors. A key bacterial behavior influenced by sub-lethal antibiotic doses is biofilm formation, a multicellular, surface-associated mode of growth. This review explores different contexts in which natural and clinical antibiotics act as modulators of bacterial biofilm formation. We discuss cases that provide mechanistic insights into antibiotic modes of action, highlighting emerging common patterns and novel findings that pave the way for future research.
抗生素被广泛用于治疗细菌感染，这使得人们普遍认为其唯一功能是抑制细菌生长或杀死细菌。然而，现在已经清楚的是，当抗生素以非致死浓度作用于敏感细菌时，它们会发挥额外的功能，这些功能会显著影响细菌生理，塑造个体和群体行为。受亚致死剂量抗生素影响的一个关键细菌行为是生物膜形成，这是一种多细胞、与表面相关的生长模式。本综述探讨了天然抗生素和临床抗生素作为细菌生物膜形成调节剂的不同情况。我们讨论了一些案例，这些案例提供了对抗生素作用模式的机制性见解，突出了新出现的共同模式和新发现，为未来的研究铺平了道路。
