Harnik Michael Alexander, Kindl Gudrun, Birklein Frank, Rittner Heike L
Klinik für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie, Zentrum für interdisziplinäre Schmerzmedizin (ZiS), Universitätsklinikum Würzburg, Oberdürrbacher Straße 6, 97080, Würzburg, Deutschland.
Universitätsklinik für Anaesthesiologie und Schmerzmedizin, Inselspital, Universität Bern, Bern, Schweiz.
Schmerz. 2025 Jun;39(3):221-231. doi: 10.1007/s00482-024-00856-4. Epub 2025 Jan 20.
Complex regional pain syndrome (CRPS) is a severe pain disorder with an unclear pathophysiology. Biomarkers offer opportunities to enhance diagnosis, stratification, prognosis, and monitoring. Serum markers such as cytokines and microRNAs show potential but require further research. Local skin markers, particularly pro-inflammatory cytokines, are elevated in the acute stage and correlate with disease activity. Imaging techniques such as skeletal scintigraphy and functional magnetic resonance imaging provide valuable insights into structural and functional changes, despite inconsistent results to date. Psychosocial factors, including pain intensity and psychological comorbidities, are important prognostic indicators. Future research should focus on specific biomarkers to develop mechanism-based treatments. A multidisciplinary approach remains crucial for effective treatment.
复杂性区域疼痛综合征（CRPS）是一种病理生理学尚不明确的严重疼痛性疾病。生物标志物为加强诊断、分层、预后评估及监测提供了契机。细胞因子和微小RNA等血清标志物显示出了潜力，但仍需进一步研究。局部皮肤标志物，尤其是促炎细胞因子，在急性期会升高，且与疾病活动相关。尽管迄今为止结果并不一致，但骨骼闪烁显像和功能磁共振成像等成像技术能为结构和功能变化提供有价值的见解。心理社会因素，包括疼痛强度和心理合并症，是重要的预后指标。未来的研究应聚焦于特定生物标志物以开发基于机制的治疗方法。多学科方法对于有效治疗仍然至关重要。
