Wang Ximing, Sun Jingxiang, Chang Na, Liu Menghan, Zhang Shuai
Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwu Road, Jinan, Shandong, 251200, China.
Department of Radiology, The First Affiliated Hospital of Shandong First Medical University, No.16766 Jingshi Road, Jinan, Shandong, 251200, China.
BMC Med Imaging. 2025 Jan 20;25(1):24. doi: 10.1186/s12880-025-01559-7.
The purpose of our study was to investigate the association between non-alcoholic fatty liver disease (NAFLD) and abdominal aortic aneurysms (AAA) progression using non-enhanced computed tomography (CT) and CT angiography (CTA).
Patients with AAA and age- and sex-matched healthy subjects who underwent abdominal CTA and non-enhanced CT examination between January 2015 and January 2023 from four hospitals were retrospectively analyzed. Patients with AAA were divided into progression (growth rate > 10 mL/year) and non-progression groups, as well as those with NAFLD and without NAFLD, based on abdominal CT results. The Kaplan-Meier and Cox regression were used to investigate the association between NAFLD and AAA progression.
A total of 151 patients with AAA (mean age: 69.1 ± 10.5 years old, 133 men) were included, among which 66 patients (43.7%) had NAFLD. During a median of 10.7 months (6.0-76.0 months), 57 patients (37.7%) had AAA progression. The prevalence of NAFLD was significantly higher in the AAA group compared to the control group (43.7% vs. 31.1%, p = 0.024). Multivariable regression analysis revealed that the NAFLD was independently associated with AAA progression (HR, 4.28; 95% CI, 2.20-8.31; p < 0.001). The area under curve of combined NAFLD and AAA maximal diameter was 0.857 for predicting AAA progression.
NAFLD on non-enhanced CT is an independent predictor of AAA progression. It can improve the diagnostic efficacy of predicting the progression of abdominal aortic aneurysms.
Not applicable. This research is a retrospective analysis.
我们研究的目的是使用非增强计算机断层扫描（CT）和CT血管造影（CTA）来调查非酒精性脂肪性肝病（NAFLD）与腹主动脉瘤（AAA）进展之间的关联。
对2015年1月至2023年1月期间来自四家医院接受腹部CTA和非增强CT检查的AAA患者以及年龄和性别匹配的健康受试者进行回顾性分析。根据腹部CT结果，将AAA患者分为进展组（生长速率>10 mL/年）和非进展组，以及有无NAFLD组。采用Kaplan-Meier法和Cox回归分析来研究NAFLD与AAA进展之间的关联。
共纳入151例AAA患者（平均年龄：69.1±10.5岁，133例男性），其中66例（43.7%）患有NAFLD。在中位10.7个月（6.0 - 76.0个月）期间，57例（37.7%）患者出现AAA进展。AAA组中NAFLD的患病率显著高于对照组（43.7%对31.1%，p = 0.024）。多变量回归分析显示，NAFLD与AAA进展独立相关（HR，4.28；95%CI，2.20 - 8.31；p < 0.001）。NAFLD与AAA最大直径联合预测AAA进展的曲线下面积为0.857。
非增强CT上的NAFLD是AAA进展的独立预测因素。它可以提高预测腹主动脉瘤进展的诊断效能。
不适用。本研究为回顾性分析。
