Parra-Izquierdo Viviana, Otero-Regino William, Juliao-Baños Fabian, Frías-Ordoñez Juan Sebastián, Ibañez-Pinilla Edgar, Gil-Parada Fabio Leonel, Marulanda-Fernández Hernando, Otero-Parra Lina, Otero-Ramos Elder, Puentes-Manosalva Fabian Eduardo, Guzmán Rojas Gerardo Andrés, Ernest-Suárez Kenneth, Villa-Ovalles Keyla, Paredes-Mendez Juan Eloy, Jara-Alba María Luisa, Andrade-Zamora David, Ardila-Báez Manuel Alonso, Flórez-Sarmiento Cristian, Veitia Guillermo, Sánchez Abel, Arango-Molano Lazaro Antonio, Fluxa Fernando, Freitas Queiroz Natália Sousa, Serrano Mariastella
Gastroenterology and Rheumatology, International Hospital of Colombia, Bucaramanga, Colombia.
Cellular and Molecular Immunology Group (INMUBO), Universidad El Bosque, Bogotá, Colombia.
Crohns Colitis 360. 2025 Jan 14;7(1):otae081. doi: 10.1093/crocol/otae081. eCollection 2025 Jan.
The prevalence of colorectal cancer (CRC) in patients with ulcerative colitis (UC) is higher than in the general population, in Latin America there is a progressive increase of UC, and information about CRC screening in inflammatory bowel disease (IBD) is scarce. The aim of this study was to analyze the findings of endoscopic surveillance of CRC in patients with IBD according to available technology.
Multicenter, cross-sectional, analytical study conducted in Latin American countries, in patients with UC, predominantly with more than 8 years of diagnosis and different degrees of disease activity. Surveillance colonoscopies were performed according to available technology. Risk factors for dysplasia detection were analyzed.
One hundred and forty-four patients, 55.5% women, mean age 47.3 (range 17.1 to 90; SD 15.64) years and mean duration of disease 12.71 (range 0.64 to 57.13; SD 8.08) years. Forty-nine lesions were identified, 18 corresponded to dysplasia. The detection rate of dysplasia per lesion and per procedure was 36.7% and 12.5%, respectively. By logistic regression analysis, the duration of disease (OR 1.12;95%CI:1.047 to 1.215, = .002) and the presence of post-inflammatory polyps (OR 3.4;95%CI:1.11 to 10.36, = .031) were risk factors for higher detection of dysplasia. Digital chromoendoscopy was associated with greater detection of dysplasia (OR 4.99, 95%CI: 1.092 to 22.864, = .038).
In our region, the duration of disease and the presence of post-inflammatory polyps were the factors with the highest association for dysplasia detection, and digital chromoendoscopy with directed biopsies was the technique of choice. The implementation of a specific surveillance program in colonoscopy in IBD is an effective strategy to achieve high detection rates.
溃疡性结肠炎（UC）患者的结直肠癌（CRC）患病率高于普通人群，在拉丁美洲，UC的发病率呈逐年上升趋势，而关于炎症性肠病（IBD）患者CRC筛查的信息却很少。本研究旨在根据现有技术分析IBD患者CRC内镜监测的结果。
在拉丁美洲国家进行的多中心、横断面分析研究，研究对象为UC患者，主要是诊断超过8年且疾病活动程度不同的患者。根据现有技术进行结肠镜监测。分析发育异常检测的危险因素。
144例患者，女性占55.5%，平均年龄47.3岁（范围17.1至90岁；标准差15.64），平均病程12.71年（范围0.64至57.13年；标准差8.08）。共发现49个病变，其中18个为发育异常。每个病变和每次检查的发育异常检出率分别为36.7%和12.5%。通过逻辑回归分析，病程（OR 1.12；95%CI：1.047至1.215，P = 0.002）和炎症后息肉的存在（OR 3.4；95%CI：1.11至10.36，P = 0.031）是发育异常检出率较高的危险因素。数字染色内镜检查与更高的发育异常检出率相关（OR 4.99，95%CI：1.092至22.864，P = 0.038）。
在我们地区，病程和炎症后息肉的存在是与发育异常检测关联度最高的因素，数字染色内镜引导活检是首选技术。在IBD患者中实施特定的结肠镜监测计划是实现高检出率的有效策略。
