Minghong Liu, Feng Qizhu, Chen Huichun, Li Ju, Shi Jun
Department of Anesthesiology, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, Anhui, China.
Department of General Surgery, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, Anhui, China.
Front Cardiovasc Med. 2025 Jan 6;11:1453608. doi: 10.3389/fcvm.2024.1453608. eCollection 2024.
We intended to observe the effects of different doses of remimazolam besylate via intravenous induction on the quality of sedation and cardiac function in elderly patients.
A total of 135 ASA I-III patients undergoing elective laparoscopic cholecystectomy were selected. They were divided into three groups and they were randomized. Low dose group (Group L): Remimazolam besylate 0.2 mg/kg; middle dose group (Group M): Remimazolam besylate 0.3 mg/kg; High dose group (Group H): Remimazolam besylate 0.4 mg/kg. There were 45 patients in each group. The blood pressure, heart rate, BIS values, cardiac function before induction (T), after induction (T) and after intubation (T), as well as the length of loss of consciousness, duration of sedation, and extubation and adverse events were recorded.
At T and T, systolic and diastolic blood pressure in Group M were lower than those in Group L, but higher than those in Group H, with statistically significant differences ( < 0.05). At T and T, the BIS value in Group M was lower than that in Group L, with a statistically significant difference ( < 0.05). However, there was no statistically significant difference ( 005) in BIS values between Group M and Group H; At T and T, the cardiac output and stroke volume in Group M were higher than those in Group H, while the systemic vascular resistance in Group M was lower than that in Group H, with statistically significant differences ( < 0.05); The incidences of bucking when moving and hiccup in Group L were higher than those in Group M and Group H, with statistically significant differences ( < 0.05). The number of vasoactive drugs used in Group H was higher than that in Group L and Group M, with statistically significant differences ( < 0.05).
General anesthesia induction with remimazolam besylate at 0.3 mg/kg in elderly patients undergoing laparoscopic cholecystectomy showed good quality of sedation, could achieve rapid intubation, with minimal effect on cardiac function and generally favorable safety profile.
我们旨在观察不同剂量苯磺酸瑞马唑仑静脉诱导对老年患者镇静质量和心功能的影响。
选取135例拟行择期腹腔镜胆囊切除术的ASA I-III级患者。将他们分为三组并随机分组。低剂量组（L组）：苯磺酸瑞马唑仑0.2mg/kg；中剂量组（M组）：苯磺酸瑞马唑仑0.3mg/kg；高剂量组（H组）：苯磺酸瑞马唑仑0.4mg/kg。每组45例患者。记录诱导前（T₁）、诱导后（T₂）和插管后（T₃）的血压、心率、BIS值、心功能，以及意识消失时间、镇静持续时间、拔管情况和不良事件。
在T₂和T₃时，M组的收缩压和舒张压低于L组，但高于H组，差异有统计学意义（P<0.05）。在T₂和T₃时，M组的BIS值低于L组，差异有统计学意义（P<0.05）。然而，M组和H组之间的BIS值差异无统计学意义（P>0.05）；在T₂和T₃时，M组的心输出量和每搏输出量高于H组，而M组的全身血管阻力低于H组，差异有统计学意义（P<0.05）；L组移动时呛咳和呃逆的发生率高于M组和H组，差异有统计学意义（P<0.05）。H组血管活性药物的使用数量高于L组和M组，差异有统计学意义（P<0.05）。
在接受腹腔镜胆囊切除术的老年患者中，0.3mg/kg苯磺酸瑞马唑仑全身麻醉诱导显示出良好的镇静质量，可实现快速插管，对心功能影响最小，且安全性总体良好。
