Chen Jiajia, Dong Shujun
The First Outpatient Department, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun, China.
Front Pharmacol. 2025 Jan 6;15:1533964. doi: 10.3389/fphar.2024.1533964. eCollection 2024.
Periodontitis is a chronic inflammatory condition driven by plaque-associated microorganisms, where uncontrolled bacterial invasion and proliferation impair host immune responses, leading to localized periodontal tissue inflammation and bone destruction. Conventional periodontal therapies face challenges, including incomplete microbial clearance and the rise of antibiotic resistance, limiting their precision and effectiveness in managing periodontitis. Recently, nanotherapies based on polymeric materials have introduced advanced approaches to periodontal antimicrobial therapy through diverse antimicrobial mechanisms. This review explored specific mechanisms, emphasizing the design of polymer-based agents that employ individual or synergistic antimicrobial actions, and evaluated the innovations and limitations of current strategies while forecasting future trends in antimicrobial development for periodontitis.
牙周炎是一种由菌斑相关微生物驱动的慢性炎症性疾病，其中不受控制的细菌入侵和增殖会损害宿主免疫反应，导致局部牙周组织炎症和骨质破坏。传统的牙周治疗面临挑战，包括微生物清除不完全和抗生素耐药性的增加，限制了它们在治疗牙周炎方面的精准性和有效性。最近，基于聚合物材料的纳米疗法通过多种抗菌机制为牙周抗菌治疗引入了先进方法。本综述探讨了具体机制，重点介绍了采用个体或协同抗菌作用的聚合物基药物的设计，并评估了当前策略的创新和局限性，同时预测了牙周炎抗菌治疗的未来发展趋势。
