Hao Yanan, Du Xin, Cai Chang, Zhao Yong, Ren Yonglin
The Institute of Brain Science and Brain-inspired Research, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
College of Environmental and Life Sciences, Murdoch University, Perth, WA, Australia.
Front Cell Infect Microbiol. 2025 Jan 6;14:1449453. doi: 10.3389/fcimb.2024.1449453. eCollection 2024.
Ammonia (NH) and hydrogen sulfide (HS) are produced during digestion in the human gut, yet the impact of these internally generated gases on male reproduction have received limited attention in scientific research.
We systematically reviewed 935 scientific publications, spanning from 1947 to 2023, focusing on external or internal NH and/or HS, male infertility, and gut microbiota. Meta-analysis was conducted to evaluate the summary relative risk (RR) and 95% confidence intervals (CIs) of combined studies.
Our findings revealed that the internal NH and/or HS were negatively related to the , which is beneficial to male fertility, whereas NH and HS were positively related to , which showed negative effects on male fertility. The meta-analysis comparing and levels with NH showed statistically significant results (<0.001).
The meta-analysis is the first to confirm these facts and explored the potential existence of a gut microbiota-inner gases-male fertility axis in the human gut.
氨（NH₃）和硫化氢（H₂S）在人体肠道消化过程中产生，但这些内源性气体对男性生殖的影响在科学研究中受到的关注有限。
我们系统回顾了1947年至2023年的935篇科学出版物，重点关注外部或内部的NH₃和/或H₂S、男性不育症和肠道微生物群。进行荟萃分析以评估综合研究的汇总相对风险（RR）和95%置信区间（CIs）。
我们的研究结果表明，内源性NH₃和/或H₂S与精子活力呈负相关，这对男性生育有益，而NH₃和H₂S与精子DNA碎片率呈正相关，这对男性生育有负面影响。比较精子活力和精子DNA碎片率水平与NH₃的荟萃分析显示出具有统计学意义的结果（P<0.001）。
该荟萃分析首次证实了这些事实，并探索了人体肠道中肠道微生物群-内源性气体-男性生育轴潜在的存在。
