Soin Sabrina, Mouhaffel Rama, Nhat Pham Hoang, Sainbayar Enkhtsogt, Abdelnabi Mahmoud, Ibrahim Ramzi
Author Affiliations: Department of Medicine, University of Arizona Tucson, Tucson, Arizona(Drs Soin, Mouhaffel, Nhat Pham, and Sainbayar); and Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, Arizona(Dr Abdelnabi).
J Public Health Manag Pract. 2025;31(4):E222-E225. doi: 10.1097/PHH.0000000000002122. Epub 2025 Feb 20.
Senility has been shown to negatively impact health outcomes. While national stressors have altered death trajectories for numerous diseases, little is known about the impact of the COVID-19 pandemic on senility-related outcomes.
To evaluate the impact of the COVID-19 pandemic on senility-related mortality in the United States.
DESIGN, SETTING, AND PARTICIPANTS: This is a retrospective analysis of US decedents with documented senility-related death using the CDC WONDER database. We estimated annual trends in senility-related age-adjusted mortality rates (AAMR) from 1999 to 2020 using log-linear regression models. Calculation of excess deaths attributable to the COVID-19 pandemic was completed by comparison of actual 2020 mortality rates and estimated 2020 mortality using average annual percentage changes.
A total of 510 819 senility-related deaths were identified. AAMR declined by 9.76%, from 7.48 in 1999 to 6.75 deaths per 100 000 in 2020. Year 2020 showed a marked increase in mortality, with 1.13 excess deaths per 100 000 population attributable to the COVID-19 pandemic. The COVID-19 pandemic contributed to an additional burden of mortality across both sexes, resulting in an estimated 1.18 and 0.99 per 100 000 excess deaths among females and males, respectively. The excess death rates per 100 000 for Black, White, Asian/Pacific Islander, and American Indian/Alaska Native populations were 1.84, 1.05, 0.99, and 1.16, respectively. The impact on US census regions was reflected in excess death rates, with the Northeastern, Midwestern, Southern, and Western regions seeing 1.27, 1.27, 1.39, and 0.31 excess deaths per 100 000, respectively.
These findings suggest that the pandemic had an association with excess senility-related mortality. Further investigation is warranted to identify factors that impact senility-related outcomes.
衰老已被证明会对健康结果产生负面影响。虽然全国性压力源改变了多种疾病的死亡轨迹，但关于新冠疫情对衰老相关结果的影响却知之甚少。
评估新冠疫情对美国衰老相关死亡率的影响。
设计、背景和参与者：这是一项使用美国疾病控制与预防中心（CDC）的WONDER数据库对有记录的衰老相关死亡的美国死者进行的回顾性分析。我们使用对数线性回归模型估计了1999年至2020年衰老相关年龄调整死亡率（AAMR）的年度趋势。通过比较2020年实际死亡率和使用年均百分比变化估计的2020年死亡率，完成了可归因于新冠疫情的超额死亡计算。
共确定了510819例衰老相关死亡。AAMR下降了9.76%，从1999年的每10万人7.48例降至2020年的每10万人6.75例。2020年死亡率显著上升，每10万人口中有1.13例超额死亡可归因于新冠疫情。新冠疫情导致了两性额外的死亡负担，估计女性和男性每10万人中分别有1.18例和0.99例超额死亡。黑人、白人、亚裔/太平洋岛民和美国印第安人/阿拉斯加原住民每10万人的超额死亡率分别为1.84、1.05、0.99和1.16。对美国人口普查地区的影响体现在超额死亡率上，东北部、中西部、南部和西部地区每10万人的超额死亡分别为1.27、1.27、1.39和0.31例。
这些发现表明，疫情与衰老相关的超额死亡率有关。有必要进一步调查以确定影响衰老相关结果的因素。
