Meng Qi, Wang Xinwei, Gao Yuzhong, Leslie William D, Lix Lisa M, Shi Xianbao, Kan Bo, Yang Shuman
Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China.
Front Endocrinol (Lausanne). 2025 Jan 7;15:1520229. doi: 10.3389/fendo.2024.1520229. eCollection 2024.
There are limited real-world data evidence assessing the clinical characteristics of hospitalized osteoporotic fractures in China.
To investigate the clinical characteristics of hospitalized major osteoporotic fractures in Northeast China.
We identified hospitalized fracture patients aged 50 and over from the First Affiliated Hospital of Jinzhou Medical University between January 1, 2018, and December 31, 2022. Major osteoporotic fractures including hip, vertebral, forearm and wrist, and humerus were diagnosed based on x-ray reports extracted from the electronic medical records (EMR). The cause of fracture, comorbidities, surgical methods, and anti-osteoporotic medications (AM) use were extracted from EMR.
The study population included 1823 fracture patients, 510 males and 1313 females. Over half of fracture patients were aged over 70 years. Hip fractures accounted for 68.4% of all fractures in males and 57.9% in females. For those with hip fractures, the most common sites were the femoral neck (62.9%) and intertrochanteric (35.3%). Most fractures were due to falls (81.0% in males and 80.2% in females). The two most common comorbidities for males and females were hyperlipemia (45.9% vs. 47.1%) and hypertension (38.2% vs. 41.6%). Only 4.7% males and 8.6% females were treated with AM.
Hip fractures, especially femoral neck fractures, accounted for the majority of osteoporotic fractures in a tertiary public hospital in Northeast China. Common comorbidities in these fracture patients were hyperlipemia and hypertension. There was a very low rate of AM use among these patients.
评估中国住院骨质疏松性骨折临床特征的真实世界数据证据有限。
调查中国东北地区住院主要骨质疏松性骨折的临床特征。
我们确定了2018年1月1日至2022年12月31日期间锦州医科大学附属第一医院50岁及以上的住院骨折患者。根据从电子病历（EMR）中提取的X线报告诊断包括髋部、椎体、前臂和腕部以及肱骨的主要骨质疏松性骨折。从EMR中提取骨折原因、合并症、手术方法和抗骨质疏松药物（AM）的使用情况。
研究人群包括1823例骨折患者，其中男性510例，女性1313例。超过一半的骨折患者年龄在70岁以上。髋部骨折在男性所有骨折中占68.4%，在女性中占57.9%。对于髋部骨折患者，最常见的部位是股骨颈（62.9%）和转子间（35.3%）。大多数骨折是由于跌倒（男性为81.0%，女性为80.2%）。男性和女性最常见的两种合并症是高脂血症（45.9%对47.1%）和高血压（38.2%对41.6%）。只有4.7%的男性和8.6%的女性接受了抗骨质疏松药物治疗。
在中国东北地区的一家三级公立医院中，髋部骨折，尤其是股骨颈骨折，占骨质疏松性骨折的大多数。这些骨折患者常见的合并症是高脂血症和高血压。这些患者中抗骨质疏松药物的使用率非常低。
