Liang Zhitang, Huang Renhao, Zhang Lingyun
General Practice Department, Binzhou Medical University, Yantai, Shandong, China.
Front Med (Lausanne). 2025 Jan 7;11:1467773. doi: 10.3389/fmed.2024.1467773. eCollection 2024.
To explore the connection between metabolic parameters and the severity of hepatic steatosis determined through ultrasound in elderly individuals with metabolic dysfunction-associated fatty liver disease (MAFLD).
4,663 senior individuals who were 65 years of age or older were included in this research. They were examined physically at the Ninghai Street Community Health Service Center in Yantai City between June 7, 2021, and October 15, 2021. There were two categories of individuals identified: the MAFLD group ( = 2,985) and the non-MAFLD group ( = 1,678). Based on liver ultrasonography results, individuals in the MAFLD group were further separated into three groups: mild ( = 2,104), moderate ( = 766), and severe ( = 115). To identify indicators of risk for the severity of hepatic steatosis, metabolic data was contrasted between the groups employing logistic regression.
In comparison to the non-MAFLD group, the MAFLD group showed significantly elevated levels of body mass index (BMI), blood pressure, gender, age, lipid profile, alanine transaminase (ALT), and fasting blood glucose (FBG; < 0.05). Among individuals with MAFLD, there was a positive correlation between BMI, FBG, ALT, and aspartate transaminase (AST) levels and the severity of hepatic steatosis ( < 0.05). Logistic regression analysis indicated that BMI, female gender, FBG, ALT, triglycerides (TG), and serum uric acid (SUA) constituted risk factors for increased severity of hepatic steatosis in MAFLD.
The severity of hepatic steatosis in elderly MAFLD patients is significantly correlated with female gender, BMI, ALT, FBG, TG, and SUA.
探讨代谢功能障碍相关脂肪性肝病（MAFLD）老年患者代谢参数与超声测定的肝脂肪变性严重程度之间的联系。
本研究纳入了4663名65岁及以上的老年人。他们于2021年6月7日至2021年10月15日在烟台市宁海街道社区卫生服务中心接受体检。确定了两类个体：MAFLD组（n = 2985）和非MAFLD组（n = 1678）。根据肝脏超声检查结果，MAFLD组个体进一步分为三组：轻度（n = 2104）、中度（n = 766）和重度（n = 115）。为了确定肝脂肪变性严重程度的风险指标，采用逻辑回归对各组之间的代谢数据进行对比。
与非MAFLD组相比，MAFLD组的体重指数（BMI）、血压、性别、年龄、血脂谱、丙氨酸转氨酶（ALT）和空腹血糖（FBG）水平显著升高（P < 0.05）。在MAFLD个体中，BMI、FBG、ALT和天冬氨酸转氨酶（AST）水平与肝脂肪变性严重程度呈正相关（P < 0.05）。逻辑回归分析表明，BMI、女性性别、FBG、ALT、甘油三酯（TG）和血清尿酸（SUA）是MAFLD中肝脂肪变性严重程度增加的危险因素。
老年MAFLD患者的肝脂肪变性严重程度与女性性别、BMI、ALT、FBG、TG和SUA显著相关。
