Chen Xing-Yu, Lan Xiang
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
World J Gastroenterol. 2025 Jan 21;31(3):99358. doi: 10.3748/wjg.v31.i3.99358.
Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally, and effective treatments are urgently needed. The present study aimed to investigate the inhibitory effect of Calculus Bovis (CB) on liver cancer and the underlying mechanisms. CB inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway, thereby suppressing the proliferation of liver cancer cells. The inhibitory effect on liver cancer growth was confirmed by both and experiments (detailed by Huang ). The present study provides a theoretical basis for the application of CB for the treatment of liver cancer, providing new avenues for liver cancer treatment.
肝细胞癌是全球癌症相关死亡的主要原因之一，迫切需要有效的治疗方法。本研究旨在探讨牛黄对肝癌的抑制作用及其潜在机制。牛黄抑制M2肿瘤相关巨噬细胞极化并调节Wnt/β-连环蛋白信号通路，从而抑制肝癌细胞的增殖。体内和体外实验均证实了其对肝癌生长的抑制作用（由黄[具体姓名]详细阐述）。本研究为牛黄在肝癌治疗中的应用提供了理论依据，为肝癌治疗提供了新的途径。
