Chen Jian-Qiang, Lan Xiang
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
World J Gastroenterol. 2025 Mar 7;31(9):99459. doi: 10.3748/wjg.v31.i9.99459.
In this paper, the mechanism of the Wnt/β-catenin pathway is introduced, and the process and principle of the experiment conducted by Huang is explained. We discussed the reliability of the conclusion that () inhibits M2 tumor-associated macrophage polarization Wnt/β-catenin pathway modulation to suppress liver cancer. We also offer suggestions for further studies of the use of in the treatment of liver cancer.
本文介绍了Wnt/β-连环蛋白信号通路的机制，并解释了Huang所进行实验的过程和原理。我们讨论了通过Wnt/β-连环蛋白信号通路调节抑制M2肿瘤相关巨噬细胞极化从而抑制肝癌这一结论的可靠性。我们还为进一步研究其在肝癌治疗中的应用提供了建议。
