Wang Mengqi, Huang Xiangqian, Ding Yuchuan, Ji Xunming, Meng Ran
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
Clin Appl Thromb Hemost. 2025 Jan-Dec;31:10760296241309630. doi: 10.1177/10760296241309630.
Hematologic diseases are considered important contributors to cerebral venous sinus thrombosis (CVST) cases. This retrospective study aims to compare the difference of the clinical and radiological characters between CVST patients with and without hematologic diseases. Consecutive hospitalized CVST patients with hematologic disorders constituted the hematologic disorder group, while that without identifiable risk factors comprised the control group in this study. We systematically documented the various types of hematologic diseases associated with CVST, along with laboratory tests. Clinical manifestations, imaging findings, as well as treatment and prognosis, were recorded. A comparative analysis was conducted between the hematologic disorder group and the control group based on the aforementioned parameters. The final analysis included 97 CVST cases associated with hematologic diseases and 65 cases without any identified risk factors. The spectrum of hematologic diseases in our study ranged from iron-deficiency anemia to acute leukemia. Patients with hematologic disorder showed higher admission mRS, greater thrombotic burden, and higher incidence of stroke and cerebral hemorrhage (p < 0.05). The use of batroxobin significantly improved the prognosis of CVST caused by hematologic diseases, without causing major bleeding or death during the follow-up period. Patients with hematologic disorders who develop CVST tend to present with more severe conditions compared to those without identifiable risk factors. It is essential to conduct timely screening for CVST in patients with hematologic diseases who present with risk factors of thrombosis.
血液系统疾病被认为是导致脑静脉窦血栓形成（CVST）病例的重要因素。本回顾性研究旨在比较患有和未患有血液系统疾病的CVST患者在临床和影像学特征上的差异。本研究中，连续住院的患有血液系统疾病的CVST患者构成血液系统疾病组，而无明确危险因素的患者构成对照组。我们系统记录了与CVST相关的各种血液系统疾病类型以及实验室检查结果。记录了临床表现、影像学表现以及治疗和预后情况。基于上述参数对血液系统疾病组和对照组进行了比较分析。最终分析纳入了97例与血液系统疾病相关的CVST病例和65例无任何明确危险因素的病例。我们研究中的血液系统疾病谱涵盖了从缺铁性贫血到急性白血病。患有血液系统疾病的患者入院时改良Rankin量表（mRS）评分更高、血栓负荷更大，且中风和脑出血的发生率更高（p < 0.05）。使用巴曲酶显著改善了由血液系统疾病引起的CVST的预后，在随访期间未导致严重出血或死亡。与无明确危险因素的患者相比，患有血液系统疾病且发生CVST的患者往往病情更严重。对于存在血栓形成危险因素的血液系统疾病患者，及时进行CVST筛查至关重要。
