Boateng Christian Akuamoah, Afatodzie Millicent Selassie, McLure Angus, Kwansa-Bentum Bethel, de Souza Dziedzom K
Department of Parasitology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana; Department of Animal Biology and Conservation Science, School of Biological Sciences, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
Department of Parasitology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
Int J Infect Dis. 2025 Mar;152:107790. doi: 10.1016/j.ijid.2025.107790. Epub 2025 Jan 20.
A survey was conducted 10 years after stopping MDA in the Gomoa West District of Ghana to assess the Wuchereria bancrofti prevalence in both human and mosquito populations.
In seven communities, infection in humans was assessed using the filariasis test strip (FTS). Mosquitoes were collected once a month over six months using pyrethrum spray catches (PSC). The mosquitoes were analyzed for W. bancrofti infections, using dissection followed by poolscreening PCR.
FTS results showed that 2/524 (0.38%; 95% CI, 0.0%-0.9%) individuals tested positive for antigen. Dissections revealed W. bancrofti infections in 5/107 Anopheles gambiae (4.7%: 95% CI, 2.2-8.5) from one community, with three mosquitoes harboring L3 larvae (2.8%: 95% CI, 0.9-7.5). PCR analysis of 683 mosquitoes in 57 pools revealed seven positive pools from two communities. The prevalence of infected mosquitoes by PCR for the district was 3.1% (95% CI, 0.5-24.0) for An. gambiae and 2.5% (95% CI, 0.4-23.5) for all Anopheles spp.
The infection rate in the Anopheles spp. exceeds the provisional 1% threshold suggested by WHO, indicating ongoing transmission risk ten years after stopping MDA. Further district-wide assessments are recommended to inform the scope of any interventions required in the Gomoa West district.
在加纳戈莫阿西区停止大规模药物喷洒（MDA）10年后进行了一项调查，以评估班氏吴策线虫在人类和蚊虫群体中的流行情况。
在7个社区，使用丝虫病检测试纸条（FTS）评估人类感染情况。在6个月内每月使用除虫菊酯喷雾捕捉法（PSC）收集一次蚊子。对蚊子进行解剖，然后通过混合样本筛查聚合酶链反应（PCR）分析班氏吴策线虫感染情况。
FTS结果显示，2/524（0.38%；95%置信区间，0.0%-0.9%）的个体抗原检测呈阳性。解剖发现，来自一个社区的107只冈比亚按蚊中有5只感染了班氏吴策线虫（4.7%：95%置信区间，2.2-8.5），其中3只蚊子携带L3幼虫（2.8%：95%置信区间，0.9-7.5）。对57个样本池中的683只蚊子进行PCR分析，发现来自两个社区的7个样本池呈阳性。该地区按PCR检测的感染蚊子患病率，冈比亚按蚊为3.1%（95%置信区间，0.5-24.0），所有按蚊属为2.5%（95%置信区间，0.4-23.5）。
按蚊属的感染率超过了世界卫生组织建议的临时1%阈值，表明在停止MDA十年后仍存在持续传播风险。建议在戈莫阿西区进行进一步的全区评估，以确定所需任何干预措施的范围。
