Smit Frerik, van Zwieten Anita, Sherrington Catherine, Franco Marcia R, Cullati Stéphane, Blyth Fiona M, Khalatbari-Soltani Saman
The University of Sydney School of Public Health, Sydney, New South Wales, Australia.
Centre for Kidney Research, Children's Hospital at Westmead, Westmead, New South Wales, Australia.
BMJ Open. 2025 Jan 21;15(1):e087971. doi: 10.1136/bmjopen-2024-087971.
Individuals experiencing disadvantaged socioeconomic positions (SEPs) may be at increased risk of falls during middle and older age, and these impacts of socioeconomic factors may vary according to the duration, timing and sequencing of exposures across the life course. However, there has not been a recent systematic review of this evidence. This study, therefore, aims to synthesise existing knowledge on the association between SEP across the life course and falls within middle- and older-aged adults.
We systematically searched for literature in three academic databases from database inception to 15 March 2024: MEDLINE (Ovid), Embase (Ovid) and PsycInfo (Ovid). The search strategy combined MeSH headings and search terms related to SEP, falls, middle- and older-aged adults and observational studies. Cohort, case-control and cross-sectional studies with mean or median participant age of >40 years, which report on the association between at least one socioeconomic indicator across the life course and one fall outcome and are published in peer-reviewed academic journals were included. No language or geographic restrictions were imposed. Titles and abstracts were screened by one reviewer with 20% of titles and abstracts also screened by a second reviewer. Two reviewers independently screened full texts. Data will be extracted using a standardised Excel template. Using a modified Quality in Prognosis Studies (QUIPS) tool, the risk of bias of included studies will be assessed by one reviewer with 20% of studies also independently appraised by a second reviewer. Meta-analyses will be conducted if sufficient homogeneity between studies permits. Otherwise, a narrative synthesis of results will be undertaken.
As this is a review of published literature, no ethics approval is required. Findings will be disseminated through a journal article publication, conference presentations and plain-text summaries for public accessibility.
CRD42024534813.
社会经济地位（SEP）处于不利状况的个体在中老年时期可能跌倒风险增加，且社会经济因素的这些影响可能因一生当中暴露的持续时间、时间点和顺序而异。然而，近期尚未对这方面的证据进行系统综述。因此，本研究旨在综合现有关于一生当中的SEP与中老年成年人跌倒之间关联的知识。
我们从数据库建立至2024年3月15日在三个学术数据库中系统检索文献：MEDLINE（Ovid）、Embase（Ovid）和PsycInfo（Ovid）。检索策略结合了与SEP、跌倒、中老年成年人及观察性研究相关的医学主题词（MeSH）和检索词。纳入参与者平均或中位年龄大于40岁、报告了一生当中至少一项社会经济指标与一项跌倒结局之间的关联且发表在同行评审学术期刊上的队列研究、病例对照研究和横断面研究。不设语言或地理限制。由一名评审员筛选标题和摘要，20%的标题和摘要也由另一名评审员筛选。两名评审员独立筛选全文。将使用标准化的Excel模板提取数据。使用改良的预后研究质量（QUIPS）工具，由一名评审员评估纳入研究的偏倚风险，20%的研究也由另一名评审员独立评估。如果研究之间有足够的同质性，则进行荟萃分析。否则，将对结果进行叙述性综合。
由于这是对已发表文献的综述，无需伦理批准。研究结果将通过期刊文章发表、会议报告以及供公众获取的纯文本摘要进行传播。
PROSPERO注册号：CRD42024534813。
