Behrens Annika S, Beckmann Matthias W, Fasching Peter A, Huebner Hanna, Emons Julius
Universitätsklinikum Erlangen, Frauenklinik, Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstraße 21-23, 91054, Erlangen, Deutschland.
Radiologie (Heidelb). 2025 Mar;65(3):194-200. doi: 10.1007/s00117-024-01410-0. Epub 2025 Jan 22.
The concept of personalized medicine is becoming increasingly important. The possibilities of diagnostics include not only genetic and molecular tumor profiles, but also the use of precise and individual imaging techniques.
The development and implementation of suitable diagnostic procedures with high sensitivity and specificity, which are at the same time tailored to the individual risk factors and biological characteristics of the patient, remain a challenge.
To enable personalized profiling, comprehensive diagnostics must be established that take into account all parameters such as imaging, molecular and genetic markers as well as real-world data and the use of artificial intelligence. This article sheds light on different approaches to personalized diagnostics in breast cancer and highlights the current clinical standard, innovative areas of research and the resulting challenges.
The highest hurdles for newer imaging techniques are the standardization of image analysis and the validation of these techniques in large clinical trials. The use of artificial intelligence requires not only appropriate technical and medical expertise, but also a sensitive approach to issues such as data protection and patient privacy. Real-world registries offer insights into real world treatment situations and are therefore of great importance.
个性化医疗的概念正变得越来越重要。诊断的可能性不仅包括基因和分子肿瘤图谱，还包括使用精确的个体化成像技术。
开发并实施具有高灵敏度和特异性、同时又能根据患者个体风险因素和生物学特征量身定制的合适诊断程序，仍然是一项挑战。
为实现个性化分析，必须建立综合诊断方法，将成像、分子和基因标志物以及真实世界数据和人工智能的应用等所有参数都考虑在内。本文阐述了乳腺癌个性化诊断的不同方法，并突出了当前的临床标准、创新研究领域以及由此产生的挑战。
更新的成像技术面临的最大障碍是图像分析的标准化以及这些技术在大型临床试验中的验证。人工智能的使用不仅需要适当的技术和医学专业知识，还需要对数据保护和患者隐私等问题采取敏感的处理方式。真实世界登记处提供了对真实世界治疗情况的洞察，因此非常重要。
