Growth-rate distributions of gut microbiota time series.

作者信息

Brigatti E, Azaele S

机构信息

Instituto de Física, Universidade Federal do Rio de Janeiro, Av. Athos da Silveira Ramos, 149, Cidade Universitária, Rio de Janeiro, RJ, 21941-972, Brazil.

Dipartimento di Fisica "G. Galilei", Università di Padova, Via Marzolo 8, 35131, Padua, Italy.

出版信息

Sci Rep. 2025 Jan 22;15(1):2789. doi: 10.1038/s41598-024-82882-x.

Abstract

Logarithmic growth-rates are fundamental observables for describing ecological systems and the characterization of their distributions with analytical techniques can greatly improve their comprehension. Here a neutral model based on a stochastic differential equation with demographic noise, which presents a closed form for these distributions, is used to describe the population dynamics of microbiota. Results show that this model can successfully reproduce the log-growth rate distribution of the considered abundance time-series. More significantly, it predicts its temporal dependence, by reproducing its kurtosis evolution when the time lag τ is increased. Furthermore, its typical shape for large τ is assessed, verifying that the distribution variance does not diverge with τ. The simulated processes generated by the calibrated stochastic equation and the analysis of each time-series, taken one by one, provided additional support for our approach. Alternatively, we tried to describe our dataset by using a logistic neutral model with an environmental stochastic term. Analytical and numerical results show that this model is not suited for describing the leptokurtic log-growth rates distribution found in our data. These results support an effective neutral model with demographic stochasticity for describing the considered microbiota.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c840/11754794/97c41eae44b1/41598_2024_82882_Fig1_HTML.jpg

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