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H2-K1 protects murine leukemia stem cells from natural killer cell-mediated immune surveillance.

作者信息

Ghosh Somadri, Rodriguez-Zabala Maria, Dushime Gladys Telliam, Reinbach Katrin, Ramakrishnan Ramprasad, Sitnicka Ewa, Järås Marcus, And Regulation Lymphoid Development

机构信息

Division of Clinical Genetics, Lund Stem Cell Center, Lund University, 22184 Lund.

Division of Molecular Hematology, Lund Stem Cell Center, Lund University, 22184 Lund.

出版信息

Haematologica. 2025 Jun 1;110(6):1389-1394. doi: 10.3324/haematol.2024.286468. Epub 2025 Jan 23.

DOI:10.3324/haematol.2024.286468
PMID:39844759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12130766/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc38/12130766/b1e8ae6d7aa4/1101389.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc38/12130766/bc44e596c467/1101389.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc38/12130766/fbecd1cbeb9b/1101389.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc38/12130766/b1e8ae6d7aa4/1101389.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc38/12130766/bc44e596c467/1101389.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc38/12130766/fbecd1cbeb9b/1101389.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc38/12130766/b1e8ae6d7aa4/1101389.fig3.jpg

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M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and improving mitochondrial metabolism.M2 巨噬细胞通过赋予吞噬作用抗性和改善线粒体代谢来驱动白血病转化。
Sci Adv. 2023 Apr 14;9(15):eadf8522. doi: 10.1126/sciadv.adf8522.
3
Chronic IL-15 Stimulation and Impaired mTOR Signaling and Metabolism in Natural Killer Cells During Acute Myeloid Leukemia.
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Front Immunol. 2021 Dec 17;12:730970. doi: 10.3389/fimmu.2021.730970. eCollection 2021.
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Cell Mol Immunol. 2021 May;18(5):1290-1304. doi: 10.1038/s41423-020-00574-8. Epub 2020 Nov 25.
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