当代坏死性软组织感染：临床病理特征及死亡预测因素分析
Necrotising soft tissue infection in the present era: an analysis of clinicopathological features and predictors of mortality.
作者信息
Anshu Dr Alok, Dwivedi Dr Surjeet, Murali Dr M, Mp Dr Harsha
机构信息
Dept of Surgery, 7 Air Force Hospital, Kanpur, India.
DNB Oncosurgery, Dept of Oncosurgery, Command Hospital Air Force, Bangalore, India.
出版信息
Surg Pract Sci. 2023 Apr 3;13:100163. doi: 10.1016/j.sipas.2023.100163. eCollection 2023 Jun.
BACKGROUND
Necrotizing soft tissue infections (NSTI) and non-NSTI are frequently difficult to distinguish based on symptoms, signs, and investigations. High morbidity related to it can only be avoided by early detection and treatment.
AIM
This study examined demographic, clinicopathological, NSTI prognosis, and mortality factors.
METHODOLOGY
80 NSTI patients were retrospectively studied. Clinicopathological profile, surgical management, histological report, and LRINEC score were included. Mortality predictions were evaluated between survivors and non-survivors.
RESULTS
73.8 percent of patients were male and the mean age was 55.4±9.6 years. Nonsurvivors averaged 11.88±0.72 LRINEC scores. Non-survivor CRP averaged 236.5±48.5 mg/l. Gp A Hemolytic Streptococci were most frequent (37.8 percent ). Diabetes was a significant mortality predictor. Total mortality was 20%.
CONCLUSION
NSTI remains a major killer. High mortality is linked to age, diabetes, higher blood creatinine, MODS, and delayed surgery." and proceed accordingly.
背景
坏死性软组织感染（NSTI）和非NSTI常常难以根据症状、体征及检查来区分。只有通过早期检测和治疗才能避免与之相关的高发病率。
目的
本研究调查了人口统计学、临床病理学、NSTI预后及死亡因素。
方法
对80例NSTI患者进行回顾性研究。纳入临床病理特征、手术治疗、组织学报告及LRINEC评分。评估幸存者与非幸存者之间的死亡预测情况。
结果
73.8%的患者为男性，平均年龄为55.4±9.6岁。非幸存者的LRINEC评分平均为11.88±0.72。非幸存者的CRP平均为236.5±48.5mg/l。A组溶血性链球菌最为常见（37.8%）。糖尿病是一个显著的死亡预测因素。总死亡率为20%。
结论
NSTI仍然是主要杀手。高死亡率与年龄、糖尿病、血肌酐升高、多器官功能障碍综合征及手术延迟有关。 并据此进行相应处理。
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