Ahmadi Pooria, Ahmadi-Renani Sajjad, Pezeshki Parmida Sadat, Nayebirad Sepehr, Jalali Arash, Shafiee Akbar, Ayati Aryan, Afzalian Arian, Alaeddini Farshid, Saadat Soheil, Masoudkabir Farzad, Vasheghani-Farahani Ali, Sadeghian Saeed, Boroumand Mohamamdali, Karimi Abbasali, Pourbashash Boshra, Hosseini Kaveh, Rosendaal Frits R
Department of Cardiology, Shariati Hospital, School of Medicine Tehran University of Medical Sciences Tehran Iran.
Tehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran Iran.
Health Sci Rep. 2025 Jan 22;8(1):e70350. doi: 10.1002/hsr2.70350. eCollection 2025 Jan.
In the current study, we aimed to identify the association between major and minor electrocardiographic abnormalities and cardiovascular risk factors.
We used the Tehran cohort study baseline data, an ongoing multidisciplinary, longitudinal study designed to identify cardiovascular disease risk factors in the adult population of Tehran. The electrocardiograms (ECGs) of 7630 Iranian adults aged 35 years and above were analyzed. ECG abnormalities were categorized into major or minor groups based on their clinical importance. Results were obtained by multivariable logistic regression and are expressed as odds ratios (ORs).
A total of 756 (9.9%) participants had major ECG abnormalities, while minor abnormalities were detected in 2526 (33.1%). Males comprised 45.8% of the total population, and 41.8% of them had minor abnormalities. Individuals with older age, diabetes (OR = 1.35; 95% CI: 1.11-1.64), and hypertension (OR = 2.21; 95% CI: 1.82-2.68) had an increased risk of major ECG abnormalities. In contrast, intermediate (OR = 0.69; 95% CI: 0.57-0.84) and high physical activity levels (OR = 0.66; 95% CI: 0.51-0.86) were associated with a lower prevalence of major abnormalities. Male sex, older age, hypertension, and current smoking were also associated with an increased prevalence of ECG abnormalities combined (major or minor).
Major and minor ECG abnormalities are linked with important cardiovascular risk factors such as diabetes and hypertension. Since these abnormalities have been associated with poor outcomes, screening patients with cardiovascular risk factors with an ECG may distinguish high-risk individuals who require appropriate care and follow-up.
在本研究中，我们旨在确定主要和次要心电图异常与心血管危险因素之间的关联。
我们使用了德黑兰队列研究的基线数据，这是一项正在进行的多学科纵向研究，旨在确定德黑兰成年人群中的心血管疾病危险因素。分析了7630名35岁及以上伊朗成年人的心电图（ECG）。根据心电图异常的临床重要性将其分为主要或次要组。通过多变量逻辑回归获得结果，并以比值比（OR）表示。
共有756名（9.9%）参与者存在主要心电图异常，而2526名（33.1%）检测到次要异常。男性占总人口的45.8%，其中41.8%有次要异常。年龄较大、患有糖尿病（OR = 1.35；95%CI：1.11 - 1.64）和高血压（OR = 2.21；95%CI：1.82 - 2.68）的个体发生主要心电图异常的风险增加。相比之下，中等（OR = 0.69；95%CI：0.57 - 0.84）和高体力活动水平（OR = 0.66；95%CI：0.51 - 0.86）与主要异常的患病率较低相关。男性、年龄较大、高血压和当前吸烟也与合并的心电图异常（主要或次要）患病率增加相关。
主要和次要心电图异常与糖尿病和高血压等重要心血管危险因素相关。由于这些异常与不良结局相关，对有心血管危险因素的患者进行心电图筛查可能会识别出需要适当护理和随访的高危个体。
