Korczyn A D, Lazarovits J, Dvilanski A, Eshel Y, Nathan I
Acta Neurol Scand. 1985 Feb;71(2):171-3. doi: 10.1111/j.1600-0404.1985.tb03184.x.
In an effort to explore possible changes in 5-hydroxytryptamine (5-HT) metabolism in idiopathic torsion dystonia (ITD), platelets from patients were studied. Platelet 5-HT concentrations did not differ from those in matched controls. 5-HT uptake by the platelets was also studied, and the results demonstrated significantly higher Km values, but Vmax values were normal among patients. Inhibition by imipramine of 5-HT uptake by platelets taken from ITD patients was also normal. The therapeutic implications of the low affinity of 5-HT to its platelet receptors are discussed.
为了探索特发性扭转性肌张力障碍（ITD）中5-羟色胺（5-HT）代谢的可能变化，对患者的血小板进行了研究。患者血小板中的5-HT浓度与匹配的对照组无差异。还研究了血小板对5-HT的摄取，结果显示患者的Km值显著更高，但Vmax值正常。丙咪嗪对ITD患者血小板摄取5-HT的抑制作用也正常。讨论了5-HT与其血小板受体低亲和力的治疗意义。
