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Serotonin uptake by blood platelets of schizophrenic patients.

作者信息

Arora R C, Meltzer H Y

出版信息

Psychiatry Res. 1982 Jun;6(3):327-33. doi: 10.1016/0165-1781(82)90022-1.

DOI:10.1016/0165-1781(82)90022-1
PMID:6955820
Abstract

Active uptake of serotonin (5-hydroxytryptamine, 5-HT) by blood platelets of acute and chronic schizophrenic patients was compared with that of normal controls. Unlike previous reports, no significant difference in the kinetic parameters (Km and Vmax) of 5-HT uptake between schizophrenic patients and normal controls was observed, although a trend toward decreased Vmax in the acute schizophrenics was present. Since decreased Vmax of platelet 5-HT uptake has been found in patients with bipolar, unipolar, and schizoaffective depression, further study of the usefulness of platelet 5-HT uptake as a biological marker for major depressive illness is indicated. Abnormalities of 5-HT uptake do not appear to contribute significantly to the increased platelet 5-HT levels which have been reported in schizophrenic patients.

摘要

相似文献

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