Li You, Yu Cheng
Department of Neurology, The Fourth Hospital of Changsha(Integrated Traditional Chinese and Western Medicine Hospital of Changsha，Changsha Hospital of Hunan Normal University）, Changsha, 410000, P.R. China.
Sci Rep. 2025 Jan 23;15(1):2989. doi: 10.1038/s41598-025-87253-8.
Neutrophil percentage-to-albumin ratio (NPAR) is a novel inflammatory biomarker and correlated with the progression and clinical outcomes of many diseases. This investigation aimed to clarified the association between NPAR and mortality risk among hypertension patients. The database of the National Health and Nutrition Examination Survey provided the patient data for hypertension. Using a restricted cubic spline (RCS), the association between the NPAR and mortality risk was investigated. In order to assess the independent risk contribution of the NPAR in all-cause and cerebrovascular mortality, weighted Cox proportional hazards models were employed. Concordance index and receiver operating characteristic (ROC) curve were employed to assess how effectively the NPAR predicted the mortality risk at different times. A total of 6,866 hypertension cases was included in this investigation. During follow-up, 2,757 (40%) patients have died, 582 (8.5%) of them from cerebrovascular disease. RCS regression analysis found a positive nonlinear correlation between NPAR and all-cause and cerebrovascular mortality of hypertension patients. High NPAR indicated higher risks of all-cause mortality (HR = 1.81, 95% CI 1.52-2.37) and cerebrovascular mortality (HR = 2.21, 95% CI 1.67-2.88) among hypertension patients, and these results remained after adjusting certain clinical parameters. The areas under the curve of for 5-year, 10-year and 15-year ROC for all-cause mortality were 0.720, 0.703 and 0.634, and those for cerebrovascular mortality were 0.705, 0.706 and 0.699, respectively. NPAR served as s a biomarker for all-cause and cerebrovascular mortality in hypertension patients. Higher NPAR indicated higher risk of all-cause and cerebrovascular mortality.
中性粒细胞百分比与白蛋白比值（NPAR）是一种新型炎症生物标志物，与多种疾病的进展和临床结局相关。本研究旨在阐明NPAR与高血压患者死亡风险之间的关联。国家健康与营养检查调查数据库提供了高血压患者的数据。使用限制立方样条（RCS）研究NPAR与死亡风险之间的关联。为了评估NPAR在全因和脑血管死亡中的独立风险贡献，采用了加权Cox比例风险模型。采用一致性指数和受试者工作特征（ROC）曲线评估NPAR在不同时间预测死亡风险的有效性。本研究共纳入6866例高血压病例。随访期间，2757例（40%）患者死亡，其中582例（8.5%）死于脑血管疾病。RCS回归分析发现，NPAR与高血压患者的全因和脑血管死亡率之间存在正非线性相关性。高NPAR表明高血压患者全因死亡风险更高（HR = 1.81，95%CI 1.52 - 2.37）和脑血管死亡风险更高（HR = 2.21，95%CI 1.67 - 2.88），在调整某些临床参数后，这些结果仍然成立。全因死亡的5年、10年和15年ROC曲线下面积分别为0.720、0.703和0.634，脑血管死亡的曲线下面积分别为0.705、0.706和0.699。NPAR可作为高血压患者全因和脑血管死亡的生物标志物。较高的NPAR表明全因和脑血管死亡风险更高。
