Cucoranu Dragoș Constantin, Pop Marian, Niculescu Raluca, Kosovski Irina-Bianca, Toganel Radu-Ovidiu, Licu Razvan-Andrei, Bacârea Anca
Radiology, Mures County Emergency Hospital, Targu Mures, ROU.
Radiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Targu Mures, ROU.
Cureus. 2023 Jun 30;15(6):e41197. doi: 10.7759/cureus.41197. eCollection 2023 Jun.
Background and objective Nonalcoholic fatty liver disease (NAFLD) is closely linked to metabolic syndrome, leading to consequences related to dyslipidemia, endothelial dysfunction, type 2 diabetes, and obesity. Due to a limited understanding of the factors contributing to the progression of NAFLD, predicting clinical outcomes in patients remains challenging. In light of this, this study aimed to evaluate the association between the occurrence of NAFLD and the neutrophil-percentage-to-albumin ratio (NPAR) as well as the neutrophil-to-lymphocyte ratio (NLR). Methods A total of 115 adult patients (mean age: 58 ± 12.5 years; 55.65% male) who underwent abdominal non-contrast-enhanced CT scans were included in the study. The analysis of CT scans was conducted to assess the attenuation values of liver parenchyma. Results There was a statistically significant difference in terms of gamma-glutamyl transpeptidase (GGT), triglyceride (TG), albumin, and NPAR between individuals with and without hepatic steatosis (GGT p<0.0001, TG p=0.0006, albumin p<0.0001, NPAR p=0.001). However, NLR values between the two groups did not show any statistical differences. NPAR (r=-0.27, p=0.0029) had a weak inverse correlation with liver attenuation value, which is expressed in Hounsfield units (HU). Conclusions Significant differences were observed in GGT, TG, albumin, and NPAR levels between individuals with and without hepatic steatosis. An inverse correlation between NPAR and liver attenuation values was also observed.
背景与目的 非酒精性脂肪性肝病（NAFLD）与代谢综合征密切相关，会导致血脂异常、内皮功能障碍、2型糖尿病和肥胖等后果。由于对导致NAFLD进展的因素了解有限，预测患者的临床结局仍然具有挑战性。鉴于此，本研究旨在评估NAFLD的发生与中性粒细胞百分比与白蛋白比值（NPAR）以及中性粒细胞与淋巴细胞比值（NLR）之间的关联。方法 本研究纳入了115例接受腹部非增强CT扫描的成年患者（平均年龄：58±12.5岁；男性占55.65%）。对CT扫描进行分析以评估肝实质的衰减值。结果 在有和没有肝脂肪变性的个体之间，γ-谷氨酰转肽酶（GGT）、甘油三酯（TG）、白蛋白和NPAR方面存在统计学显著差异（GGT p<0.0001，TG p=0.0006，白蛋白p<0.0001，NPAR p=0.001）。然而，两组之间的NLR值没有显示出任何统计学差异。NPAR（r=-0.27，p=0.0029）与以亨氏单位（HU）表示的肝脏衰减值呈弱负相关。结论 在有和没有肝脂肪变性的个体之间，观察到GGT、TG、白蛋白和NPAR水平存在显著差异。还观察到NPAR与肝脏衰减值之间呈负相关。
