Drew P A, Takezawa K
Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610-0275, USA.
Diagn Cytopathol. 1998 May;18(5):365-7. doi: 10.1002/(sici)1097-0339(199805)18:5<365::aid-dc13>3.0.co;2-g.
Pulmonary cryptococcosis was diagnosed by examining smears obtained by fine-needle aspiration (FNA) in a patient with pituitary Cushing's disease. FNA allowed for rapid diagnosis and prompt treatment of a potentially serious infection. The patient fully recovered from her pulmonary disease. Although opportunistic infections may occur in patients with endogenous Cushing's syndrome, it is rare to see such infections in the subset of patients with pituitary Cushing's disease. Hypercortisolism associated with Cushing's syndrome appears to induce a transitory immune deficiency state and opens a window of opportunity for certain infectious agents such as Cryptococcus neoformans to exploit. To our knowledge, this is the third such case reported in this clinical setting, and the first diagnosed by FNA.
通过细针穿刺抽吸（FNA）获取涂片检查，诊断出一名患有垂体库欣病的患者患有肺隐球菌病。FNA有助于对潜在的严重感染进行快速诊断和及时治疗。该患者的肺部疾病已完全康复。虽然内源性库欣综合征患者可能会发生机会性感染，但在垂体库欣病患者亚组中很少见到此类感染。与库欣综合征相关的皮质醇增多症似乎会诱发一种短暂的免疫缺陷状态，为新型隐球菌等某些感染因子创造了可乘之机。据我们所知，这是在这种临床情况下报告的第三例此类病例，也是首例通过FNA诊断的病例。
