• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Shared mechanisms and pathological phenotypes underlying aminoacyl-tRNA synthetase-related neuropathies.

作者信息

Rhymes Elena R, Sleigh James N

机构信息

Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK (Rhymes ER, Sleigh JN).

UK Dementia Research Institute, University College London, London, UK (Sleigh JN).

出版信息

Neural Regen Res. 2026 Jan 1;21(1):312-313. doi: 10.4103/NRR.NRR-D-24-01080. Epub 2024 Dec 7.

DOI:10.4103/NRR.NRR-D-24-01080
PMID:39851138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12094558/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90d4/12094558/3a8913a92e81/NRR-21-312-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90d4/12094558/3a8913a92e81/NRR-21-312-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90d4/12094558/3a8913a92e81/NRR-21-312-g001.jpg

相似文献

1
Shared mechanisms and pathological phenotypes underlying aminoacyl-tRNA synthetase-related neuropathies.氨酰-tRNA合成酶相关神经病变的共同机制和病理表型
Neural Regen Res. 2026 Jan 1;21(1):312-313. doi: 10.4103/NRR.NRR-D-24-01080. Epub 2024 Dec 7.
2
Phenotypes and genotypes of mitochondrial aminoacyl-tRNA synthetase deficiencies from a single neurometabolic clinic.来自单一神经代谢诊所的线粒体氨酰-tRNA合成酶缺陷的表型和基因型
JIMD Rep. 2019 Dec 18;51(1):3-10. doi: 10.1002/jmd2.12079. eCollection 2020 Jan.
3
Expanding a tyrosyl-tRNA synthetase assay to other aminoacyl-tRNA synthetases.将酪氨酰 - tRNA合成酶检测方法扩展至其他氨酰 - tRNA合成酶。
Data Brief. 2015 Jun 10;4:253-6. doi: 10.1016/j.dib.2015.05.021. eCollection 2015 Sep.
4
[Recognition between tRNAs and aminoacyl-tRNA-synthetases of different specificities].[不同特异性的转运RNA与氨酰转运RNA合成酶之间的识别]
Mol Biol (Mosk). 1975 Jan-Feb;9(1):48-54.
5
The role of cyclic 3',5'-AMP in the regulation of aminoacyl-tRNA synthetase activities in mouse uterus and liver following 17beta-oestradiol treatment. Activation of a phosphoaminoacyl-tRNA synthetase phosphatase by phosphorylation with cyclic 3',5'-AMP dependent protein kinase.17β-雌二醇处理后，环3',5'-腺苷酸在调节小鼠子宫和肝脏中氨酰-tRNA合成酶活性中的作用。环3',5'-腺苷酸依赖性蛋白激酶磷酸化激活磷酸化氨酰-tRNA合成酶磷酸酶。
Biochim Biophys Acta. 1978 Nov 21;521(1):274-87. doi: 10.1016/0005-2787(78)90270-8.
6
The Aminoacyl-tRNA Synthetase Complex.氨酰-tRNA合成酶复合体
Subcell Biochem. 2017;83:505-522. doi: 10.1007/978-3-319-46503-6_18.
7
Transfer RNA and small molecule therapeutics for aminoacyl-tRNA synthetase diseases.用于氨酰-tRNA合成酶疾病的转运RNA和小分子疗法。
FEBS J. 2025 Jun;292(11):2737-2750. doi: 10.1111/febs.17361. Epub 2024 Dec 19.
8
Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.人多氨酰-tRNA 合成酶复合物中回缩的赖氨酰-tRNA 合成酶-AIMP2 组装。
J Biol Chem. 2019 Mar 29;294(13):4775-4783. doi: 10.1074/jbc.RA118.006356. Epub 2019 Feb 7.
9
multi-aminoacyl-tRNA synthetase complex formation limits promiscuous tRNA proofreading.多氨酰基-tRNA合成酶复合物的形成限制了混杂的tRNA校对。
Front Microbiol. 2024 Jul 16;15:1445687. doi: 10.3389/fmicb.2024.1445687. eCollection 2024.
10
Valyl-tRNA synthetase gene of Escherichia coli K12. Primary structure and homology within a family of aminoacyl-TRNA synthetases.大肠杆菌K12的缬氨酰-tRNA合成酶基因。氨酰-tRNA合成酶家族中的一级结构与同源性。
J Biol Chem. 1988 Jan 15;263(2):868-77.

本文引用的文献

1
Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy.在 DI-CMTC 周围神经病的小鼠模型中，肌肉中 BDNF 的增加可挽救受损的轴突运输。
Neurobiol Dis. 2024 Jun 1;195:106501. doi: 10.1016/j.nbd.2024.106501. Epub 2024 Apr 6.
2
Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.增强外周 BDNF 可挽救 CMT2D 小鼠体内受损的轴突运输。
JCI Insight. 2023 May 8;8(9):e157191. doi: 10.1172/jci.insight.157191.
3
Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling.
酪氨酰-tRNA 合成酶在肌动蛋白成束中具有非典型功能。
Nat Commun. 2023 Mar 8;14(1):999. doi: 10.1038/s41467-023-35908-3.
4
tRNA overexpression rescues peripheral neuropathy caused by mutations in tRNA synthetase.tRNA 过表达可挽救 tRNA 合成酶突变引起的周围神经病。
Science. 2021 Sep 3;373(6559):1161-1166. doi: 10.1126/science.abb3356. Epub 2021 Sep 1.
5
The integrated stress response contributes to tRNA synthetase-associated peripheral neuropathy.整合应激反应导致 tRNA 合成酶相关的周围神经病。
Science. 2021 Sep 3;373(6559):1156-1161. doi: 10.1126/science.abb3414. Epub 2021 Sep 1.
6
CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS.CMT2N 致病氨酰化结构域突变体能使 Nrp1 与 AlaRS 相互作用。
Proc Natl Acad Sci U S A. 2021 Mar 30;118(13). doi: 10.1073/pnas.2012898118.
7
Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy.核定位的与腓骨肌萎缩症相关的氨酰-tRNA 合成酶引起的转录失调。
Nat Commun. 2019 Nov 6;10(1):5045. doi: 10.1038/s41467-019-12909-9.
8
CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.CMT 疾病的严重程度与组氨酰-tRNA 合成酶突变诱导的开放构象相关，而与氨酰化丧失无关，在患者细胞中。
Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19440-19448. doi: 10.1073/pnas.1908288116. Epub 2019 Sep 9.
9
Emerging mechanisms of aminoacyl-tRNA synthetase mutations in recessive and dominant human disease.隐性和显性人类疾病中氨酰-tRNA合成酶突变的新机制
Hum Mol Genet. 2017 Oct 1;26(R2):R114-R127. doi: 10.1093/hmg/ddx231.
10
Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.能够导致蛋白质错误相互作用的替代性稳定构象将氨酰tRNA合成酶与周围神经病变联系起来。
Nucleic Acids Res. 2017 Jul 27;45(13):8091-8104. doi: 10.1093/nar/gkx455.