Sim Soo Yeun, Baek In-Cheol, Cho Won Kyoung, Jung Min Ho, Kim Tai-Gyu, Suh Byung-Kyu
Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Cells. 2025 Jan 10;14(2):93. doi: 10.3390/cells14020093.
Turner syndrome (TS) can be determined by karyotype analysis, marked by the loss of one X chromosome in females. However, the genes involved in autoimmunity in TS patients remain unclear. In this study, we aimed to analyze differences in immune gene expression between a patient with TS, a healthy female, and a female patient with Graves' disease using single-cell RNA sequencing (scRNA-seq) analysis of antigen-specific CD4(+) T cells. We identified 43 differentially expressed genes in the TS patient compared with the healthy female and the female patient with Graves' disease. Many of these genes have previously been suggested to play a role in immune system regulation. This study provides valuable insights into the differences in immune-related gene expression between TS patients, healthy individuals, and those with autoimmune diseases.
特纳综合征（TS）可通过核型分析确定，其特征为女性体内一条X染色体缺失。然而，TS患者中涉及自身免疫的基因仍不清楚。在本研究中，我们旨在通过对抗原特异性CD4(+) T细胞进行单细胞RNA测序（scRNA-seq）分析，来分析一名TS患者、一名健康女性和一名格雷夫斯病女性患者之间免疫基因表达的差异。与健康女性和格雷夫斯病女性患者相比，我们在TS患者中鉴定出43个差异表达基因。其中许多基因先前已被认为在免疫系统调节中发挥作用。本研究为TS患者、健康个体和自身免疫性疾病患者之间免疫相关基因表达的差异提供了有价值的见解。
