Souêtre E, Salvati E, Pringuey D, Plasse Y, Savelli M, Darcourt G
J Affect Disord. 1987 Jan-Feb;12(1):41-6. doi: 10.1016/0165-0327(87)90059-0.
Five patients with endogenous depression were asked to participate in a phase-advance procedure consisting in advancing by 5 h the time schedule of the major external synchronizers such as light/dark, sleep/wake, meal time and social activity cycles. Clinical and biological parameters were observed throughout this 2-week process which followed one night of partial sleep deprivation. All patients improved with partial sleep deprivation and four of the five showed continuing remission during the phase-advance process. The antidepressant effects of the phase-advance process are discussed in light of different chronobiological models for depression.
五名内源性抑郁症患者被要求参与一项相位提前程序，该程序包括将主要外部同步器的时间表提前5小时，如光/暗、睡眠/觉醒、用餐时间和社交活动周期。在这一为期两周的过程中，观察临床和生物学参数，该过程在一夜部分睡眠剥夺之后进行。所有患者在部分睡眠剥夺后病情均有改善，五名患者中有四名在相位提前过程中持续缓解。根据不同的抑郁症生物钟模型讨论了相位提前过程的抗抑郁作用。
